Alexander's disease: a case report of a biopsy proven case.

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dc.contributor.authorTatke, Men_US
dc.contributor.authorSharma, Aen_US
dc.date.accessioned1999-12-08en_US
dc.date.accessioned2009-06-03T12:52:28Z
dc.date.available1999-12-08en_US
dc.date.available2009-06-03T12:52:28Z
dc.date.issued1999-12-08en_US
dc.description.abstractA case of infantile onset Alexander's disease in a two and a half year old male child is presented, who had progressively increasing macrencephaly since birth. A frontal lobe biopsy revealed collections of Rosenthal fibres in the subpial and perivascular areas with diffuse dysmyelination and presence of reactive astrocytes. The Rosenthal fibres were immunoreactive for glial fibrillary acidic protein and ubiquitin. Electron microscopic examination showed the Rosenthal fibres as intra-astrocytic and extracellular granular osmiphilic collections.en_US
dc.description.affiliationDepartment of Pathology, G.B. Pant Hospital, New Delhi, 110002, India.en_US
dc.identifier.citationTatke M, Sharma A. Alexander's disease: a case report of a biopsy proven case. Neurology India. 1999 Dec; 47(4): 333-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121843
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAge of Onseten_US
dc.subject.meshBiopsyen_US
dc.subject.meshBrain Diseases --pathologyen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurodegenerative Diseases --pathologyen_US
dc.titleAlexander's disease: a case report of a biopsy proven case.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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