Differential expression of solute carrier family 11a member 1 and inducible nitric oxide synthase 2 in skin biopsies from leprosy patients.

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dc.contributor.authorPereira-Suárez, Ana Laura
dc.contributor.authorAlvarado-Navarro, Anabell
dc.contributor.authorBarrietos-García, Juan Gabriel
dc.contributor.authorEstrada-Chávez, Ciro
dc.contributor.authorMuñoz-Valle, José Francisco
dc.contributor.authorFafutis-Morris, Mary
dc.date.accessioned2016-01-05T09:42:12Z
dc.date.available2016-01-05T09:42:12Z
dc.date.issued2015-11
dc.description.abstractBackground: Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae, an intracellular parasite that resides within macrophages and cannot be eliminated effectively. Solute carrier family 11a member 1 (Slc11a1) and inducible nitric oxide synthase (iNOS), both expressed in macrophages, play major roles in host defense against several intracellular pathogens. However, the roles of these molecules in natural infection with M. leprae remain unknown. Objective: We aimed to investigate the expression of Slc11a1 and iNOS in macrophages (CD68+ cells) infi ltrating skin lesions in leprosy. Methods: Skin biopsies from 48 Mexican patients of leprosy [(33 lepromatous (LL), 15 tuberculoid (TT)] and from 10 healthy controls, were subjected to immunohistochemistry to determine expression of CD68, Slc11a1 and iNOS. Results: We found a high expression of Slc11a1 and iNOS in most lepromatous leprosy samples. In tuberculoid leprosy samples, Slc11a1 expression was moderate or low, and that of iNOS was almost always low. In addition, Slc11a1 and iNOS expression levels were positively associated with bacillary loads in lepromatous leprosy lesions (P = 0.05). Conclusions: These observations suggest that M. leprae infection promotes the expression of Slc11a1 and iNOS in macrophages and that lepromatous leprosy can occur despite this response.en_US
dc.identifier.citationPereira-Suárez Ana Laura, Alvarado-Navarro Anabell, Barrietos-García Juan Gabriel, Estrada-Chávez Ciro, Muñoz-Valle José Francisco, Fafutis-Morris Mary. Differential expression of solute carrier family 11a member 1 and inducible nitric oxide synthase 2 in skin biopsies from leprosy patients. Indian Journal of Dermatology, Venereology and Leprology. 2015 Nov-Dec; 81(6): 594-599.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/169829
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2015;volume=81;issue=6;spage=594;epage=599;aulast=Pereira-Suárezen_US
dc.subjectImmune responseen_US
dc.subjectmacrophageen_US
dc.subjectsolute carrier family 11a member 1en_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectleprosyen_US
dc.subjectlepromatous, tuberculoiden_US
dc.subjectSlc11a1en_US
dc.subjectNRAMP1en_US
dc.subjectiNOSen_US
dc.titleDifferential expression of solute carrier family 11a member 1 and inducible nitric oxide synthase 2 in skin biopsies from leprosy patients.en_US
dc.typeArticleen_US
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