Studies on stibanate unresponsive isolates of Leishmania donovani.

Simple item page
dc.contributor.authorBhattacharyya, Aninditaen_US
dc.contributor.authorMukherjee, Mandiraen_US
dc.contributor.authorDuttagupta, Swadeshen_US
dc.date.accessioned2002-09-17en_US
dc.date.accessioned2009-06-01T14:42:22Z
dc.date.available2002-09-17en_US
dc.date.available2009-06-01T14:42:22Z
dc.date.issued2002-09-17en_US
dc.description.abstractVisceral leishmaniasis, also known as kala-azar (KA) is generally caused by Leishmania donovani. Organic pentavalent antimonials (SbV) is the first line of treatment for KA. However, the number of KA patients unresponsive to treatment with Sb(V) is steadily increasing in India and elsewhere. The primary objective of this work is to determine the factor(s) associated with the rise of unresponsiveness. Analysis of the clonal population of parasites clearly indicated that wild type parasites isolated from KA patients who were clinically cured after treatment with Sb(V), were a mixture of resistant and sensitive cells. The resistant promastigotes were also resistant as amastigotes in vivo. It was further observed that Stibanate sensitive parasites can be made resistant to the drug by repeated passages in experimental animals followed by incomplete treatment with suboptimal doses of the drug. These results suggest that the steady rise in Sb(V) unresponsiveness of KA patients in India is due to infection with resistant parasites, generated as a result of irregular and often incomplete treatment of the patientsen_US
dc.description.affiliationLeishmania Division, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata 700 032, India. anindita_72@yahoo.comen_US
dc.identifier.citationBhattacharyya A, Mukherjee M, Duttagupta S. Studies on stibanate unresponsive isolates of Leishmania donovani. Journal of Biosciences. 2002 Sep; 27(5): 503-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111017
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimonyen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshLeishmania donovani --drug effectsen_US
dc.subject.meshOrganometallic Compounds --pharmacologyen_US
dc.subject.meshTrypanocidal Agents --pharmacologyen_US
dc.titleStudies on stibanate unresponsive isolates of Leishmania donovani.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of Biosciences