Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits.

dc.contributor.authorSharma, Ien_US
dc.contributor.authorGusain, Den_US
dc.contributor.authorDixit, V Pen_US
dc.date.accessioned1991-01-01en_US
dc.date.accessioned2009-06-01T07:12:12Z
dc.date.available1991-01-01en_US
dc.date.available2009-06-01T07:12:12Z
dc.date.issued1991-01-01en_US
dc.description.abstractPlumbagin (2-methyl-5-hydroxy, 1:4 naphthoquinone) isolated from the roots of Plumbago zeylanica when administered to hyperlipidaemic rabbits, reduced serum cholesterol and LDL-Chol. by 53 to 86 percent and 61 to 91 percent respectively. It lowered cholesterol/phospholipid ratio by 45.8 percent and elevates the decreased HDL-Chol significantly. Further, Plumbagin treatment prevented the accumulation of cholesterol and triglycerides in liver and aorta and regressed atheromatous plaques of thoracic and abdominal aorta. Plumbagin treated hyperlipidaemic subjects excreted more fecal cholesterol and phospholipids. In conclusion-Plumbagin feeding brings about a definite regression of atheroma and prevents the accumulation of cholesterol and triglycerides in liver and aorta.en_US
dc.description.affiliationDepartment of Zoology, University of Rajasthan, Jaipur.en_US
dc.identifier.citationSharma I, Gusain D, Dixit VP. Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits. Indian Journal of Physiology and Pharmacology. 1991 Jan; 35(1): 10-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107975
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntilipemic Agents --pharmacologyen_US
dc.subject.meshAorta --pathologyen_US
dc.subject.meshArteriosclerosis --pathologyen_US
dc.subject.meshCholesterol --blooden_US
dc.subject.meshCholesterol, HDL --blooden_US
dc.subject.meshDiet, Atherogenicen_US
dc.subject.meshFeces --chemistryen_US
dc.subject.meshIndiaen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshNaphthoquinones --pharmacologyen_US
dc.subject.meshPhospholipids --blooden_US
dc.subject.meshPlants, Medicinalen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTriglycerides --blooden_US
dc.titleHypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits.en_US
dc.typeJournal Articleen_US
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