Long-term quality of life postacute kidney injury in cardiac surgery patients

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dc.contributor.authorMishra, Pankaj Kumaren_US
dc.contributor.authorLuckraz, Heymanen_US
dc.contributor.authorNandi, Jayantaen_US
dc.contributor.authorNevill, Alanen_US
dc.contributor.authorGiri, Rameshen_US
dc.contributor.authorPanayiotou, Andrewen_US
dc.contributor.authorNicholas, Johannen_US
dc.date.accessioned2019-12-02T09:42:37Z
dc.date.available2019-12-02T09:42:37Z
dc.date.issued2018-01
dc.description.abstractBackground: Acute renal failure after cardiac surgery is known to be associated with significant short-term morbidity and mortality. There have as yet been no major reports on long-term quality of life (QOL). This study assessed the impact of acute kidney injury (AKI) and renal replacement therapy (RRT) on long-term survival and QOL after cardiac surgery. The need for long-term RRT is also assessed. Materials and Methods: Patients who underwent cardiac surgery between 2005 and 2011 (n = 6087) and developed AKI (RIFLE criteria, n = 570) were included. They were propensity-matched 1:1 to patients without renal impairment (control). Data were prospectively collected, and health-related QOL questionnaire was sent to patients who were alive at least 1-year postoperatively at the time of the study. Results: There was no significant difference in the preoperative characteristics between the two groups (age, gender, left ventricular ejection fraction, procedure, urgency, logistic Euroscore), respectively. Median follow-up was 52 months. Survival data were available in all patients. Questionnaires were returned in 64% of eligible patients. Long-term survival was significantly lower, and QOL, in particular the physical aspect, was significantly worse for the AKI group as compared to non-AKI group (38.8 vs. 44.2, P = 0.002), especially so in patients who required RRT. In alive respondents, despite an 18% (66/359) incidence of ongoing renal follow-up, the need for late RRT was only in 1.1% (4/359). Conclusion: AKI and especially the need for RRT following cardiac surgery are associated with increased long-term mortality as well as worse quality of life in a propensity-matched control group.en_US
dc.identifier.affiliationsDepartment of Cardiothoracic Surgery, Heart and Lung Centre, Wolverhampton WV10 0QP, UKen_US
dc.identifier.affiliationsUniversity of Wolverhampton, Wolverhampton WS1 3BD, UKen_US
dc.identifier.affiliationsDepartment of Cardiothoracic Anaesthesiology, Heart and Lung Centre, Wolverhampton WV10 0QP, UKen_US
dc.identifier.affiliationsDepartment of Nephrology, Heart and Lung Centre, Wolverhampton WV10 0QP, UKen_US
dc.identifier.citationMishra Pankaj Kumar, Luckraz Heyman, Nandi Jayanta, Nevill Alan, Giri Ramesh, Panayiotou Andrew, Nicholas Johann. Long-term quality of life postacute kidney injury in cardiac surgery patients. Annals of Cardiac Anaesthesia. 2018 Jan; 21(1): 41-45en_US
dc.identifier.issn0971-9784
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/185701
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume21en_US
dc.source.urihttps://dx.doi.org/10.4103/aca.ACA_104_17en_US
dc.subjectAcute kidney injuryen_US
dc.subjectpostcardiac surgeryen_US
dc.subjectquality of lifeen_US
dc.titleLong-term quality of life postacute kidney injury in cardiac surgery patientsen_US
dc.typeJournal Articleen_US
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