Early treatment with low fixed dose (5 mCi) radioiodine therapy is effective in Indian subjects with Graves' disease.

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dc.contributor.authorSanyal, Debmalyaen_US
dc.contributor.authorMukhhopadhyay, Pradipen_US
dc.contributor.authorPandit, Kaushiken_US
dc.contributor.authorChatterjee, Jayantaen_US
dc.contributor.authorRaychaudhuri, Moutusien_US
dc.contributor.authorMukherjee, Satinathen_US
dc.contributor.authorChowdhury, Subhankaren_US
dc.date.accessioned2008-06-09en_US
dc.date.accessioned2009-05-31T09:37:30Z
dc.date.available2008-06-09en_US
dc.date.available2009-05-31T09:37:30Z
dc.date.issued2008-06-09en_US
dc.description.abstractThere is little consensus regarding the most appropriate dosage regimen for radioiodine treatment in Graves' disease. The authors evaluated the efficacy of low fixed dose (5mCi) of radioiodine therapy, in terms of its cure rate and promptness of control, as well possible factors influencing the outcome. One hundred and twenty five consecutive patients with Graves' disease with persistent disease activity despite receiving carbimazole were treated with 5 mCi fixed dose of I131. Patients, who remained hyperthyroid at 1 year, received a second dose of 7.5 mCi of I113. After first dose 73.6% were cured (36.8% hypothyroid and 36.8% euthyroid), while 26.4% patients did not respond. Those who achieved cure had significantly lesser goiter size (84.6% with grade I goiter and 70.7% with grade II) and had received significantly shorter duration of prior carbimazole therapy (22 +/- 10 months versus 63 +/- 27 months) (p < 0.01). Age, sex, baseline T3, T4, 24 hour I131 uptake did not affect the cure rate. Mean time to response was 7 +/- 4 months. One hundred and three (82.4%) patients were cured after 2 doses while only 22 (17.6%) were nonresponsive. Hence, low fixed dose (5mCi) radio active iodine (RAI) therapy seems to be effective in Graves' disease particularly in patients with small sized goiter and short duration of pretherapy with thionamides.en_US
dc.description.affiliationDepartment of Endocrinology, IPGME&R & SSKM Hospital, Kolkata.en_US
dc.identifier.citationSanyal D, Mukhhopadhyay P, Pandit K, Chatterjee J, Raychaudhuri M, Mukherjee S, Chowdhury S. Early treatment with low fixed dose (5 mCi) radioiodine therapy is effective in Indian subjects with Graves' disease. Journal of the Indian Medical Association. 2008 Jun; 106(6): 360-1, 372en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/98722
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAdulten_US
dc.subject.meshAntithyroid Agents --therapeutic useen_US
dc.subject.meshCarbimazole --therapeutic useen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraves Disease --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshIodine Radioisotopes --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Failureen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEarly treatment with low fixed dose (5 mCi) radioiodine therapy is effective in Indian subjects with Graves' disease.en_US
dc.typeJournal Articleen_US
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