Evaluation of disease modifying activity of Coriandrum sativum in experimental models.

Simple item page
dc.contributor.authorNair, Vinod
dc.contributor.authorSingh, Surender
dc.contributor.authorGupta, Y K
dc.date.accessioned2012-05-31T06:45:51Z
dc.date.available2012-05-31T06:45:51Z
dc.date.issued2012-02
dc.description.abstractBackground & objectives: Coriandrum sativum (CS), has been widely used in traditional systems of medicine for treatment of rheumatoid arthritis. However, the mechanism of action for its antiarthritic effects is not clearly known. Therefore, the present study was carried out to evaluate the antiarthritic activity of CS in rats in two experimental models. Methods: The antiarthritic activity of CS seed hydroalcoholic extract (CSHE) was evaluated in adult Wistar rats by using two experimental models, viz. formaldehyde and Complete Freund's adjuvant (CFA) induced arthritis. The expression of pro-inflammatory cytokines (predominantly contributed by macrophages) was also evaluated. TNF-α level was estimated in serum by ELISA method. TNF-R1, IL-1 β and IL-6 expression in the synovium was analysed by immunohistochemistry. Results: CSHE produced a dose dependent inhibition of joint swelling as compared to control animals in both, formaldehyde and CFA induced arthritis. Although there was a dose dependent increase in serum TNF-α levels in the CSHE treated groups as compared to control, the synovial expression of macrophage derived pro-inflammatory cytokines/cytokine receptor was found to be lower in the CSHE treated groups as compared to control. Interpretation & conclusions: Our results demonstrate that the antiarthritic activity of CSHE may be attributed to the modulation of pro-inflammatory cytokines in the synovium. In further studies CSHE could be explored to be developed as a disease modifying agent in the treatment of RA.en_US
dc.identifier.citationNair Vinod, Singh Surender, Gupta Y K. Evaluation of disease modifying activity of Coriandrum sativum in experimental models. Indian Journal of Medical Research. 2012 Feb; 135(2): 240-245.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138774
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336857/en_US
dc.subjectAdjuvant arthritisen_US
dc.subjectCoriandrum sativumen_US
dc.subjectformaldehyde induced arthritisen_US
dc.subjectpro-inflammatory cytokinesen_US
dc.subjectTNF-alphaen_US
dc.subject.meshAnimals
dc.subject.meshArthritis, Rheumatoid --chemically induced
dc.subject.meshArthritis, Rheumatoid --drug therapy
dc.subject.meshCoriandrum --adverse effects
dc.subject.meshCoriandrum --chemistry*
dc.subject.meshDisease Models, Animal
dc.subject.meshFormaldehyde --administration & dosage
dc.subject.meshFreund's Adjuvant --administration & dosage
dc.subject.meshGene Expression Regulation --drug effects
dc.subject.meshInterleukin-1beta --metabolism
dc.subject.meshInterleukin-6 --metabolism
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshPlant Extracts --therapeutic use
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSynovial Membrane --metabolism
dc.subject.meshTumor Necrosis Factor-alpha --blood
dc.titleEvaluation of disease modifying activity of Coriandrum sativum in experimental models.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmr2012v135n2p240.pdf
Size:
1020.69 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Medical Research