Autologous peripheral blood stem cell transplantation: predictors for haematopoietic reconstitution.

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dc.contributor.authorBedi, Rajeeven_US
dc.contributor.authorKumar, Laliten_US
dc.contributor.authorKochupillai, Ven_US
dc.date.accessioned2003-09-19en_US
dc.date.accessioned2009-06-03T05:44:29Z
dc.date.available2003-09-19en_US
dc.date.available2009-06-03T05:44:29Z
dc.date.issued2003-09-19en_US
dc.description44 references.en_US
dc.description.abstractAutologous peripheral blood stem cell transplantation is currently used in the treatment of various haematological and non-haematological cancers. Until recently, colony forming unit-granulocyte-macrophage (CFU-GM) assay and mononuclear cell (MNC) count were the indices commonly used to determine the quality of stem cell grafts and the haematopoietic reconstitutive capacity of transplanted stem cells. However, the discovery of CD34 as a stem cell marker has revolutionized the assessment of progenitor cells present in the peripheral blood stem cell graft. Many studies have included enumeration of CD34+ cells, MNCs and CFU-GM assay in stem cell grafts, and their correlation with engraftment has also been studied. However, there is no consensus regarding the optimum dose of each parameter that ensures haematopoietic recovery in all patients. We discuss the stem cell biology and review the literature on stem cell characteristics influencing successful haemopoietic reconstitution.en_US
dc.description.affiliationDepartment of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India.en_US
dc.identifier.citationBedi R, Kumar L, Kochupillai V. Autologous peripheral blood stem cell transplantation: predictors for haematopoietic reconstitution. National Medical Journal of India. 2003 Sep-Oct; 16(5): 255-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/118574
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAntigens, CD34 --analysisen_US
dc.subject.meshBiological Assayen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshHematologic Diseases --immunologyen_US
dc.subject.meshHematopoiesis --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshPeripheral Blood Stem Cell Transplantationen_US
dc.subject.meshResearchen_US
dc.subject.meshTransplantation, Autologousen_US
dc.titleAutologous peripheral blood stem cell transplantation: predictors for haematopoietic reconstitution.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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