Clinico-epidemiological profile of hepatitis A virus and hepatitis E virus co-infection in pediatric age group: a hospital based retrospective study

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dc.contributor.authorHanda, Shikhaen_US
dc.contributor.authorWasim, Sanoberen_US
dc.contributor.authorKalra, B. P.en_US
dc.contributor.authorRawat, Anilen_US
dc.contributor.authorChandar, Vipanen_US
dc.contributor.authorGupta, Alpaen_US
dc.date.accessioned2020-09-24T07:43:17Z
dc.date.available2020-09-24T07:43:17Z
dc.date.issued2019-03
dc.description.abstractBackground: Hepatitis-A virus (HAV) and Hepatitis E virus (HEV) are two major hepatotropic viruses of great public health importance in the developing countries like India. Both HAV and HEV are enterically transmitted and there are speculations that their co-infection might be associated with a more severe clinical course and increased rate of mortality. The objective of this study is to determine the prevalence, clinical features and biochemical parameters of Hepatitis A and Hepatitis E co-infection in hospitalized patients at a tertiary care centre in Uttarakhand.Methods: It is a retrospective study, covering a period of 4years and conducted in Himalayan Institute of Medical Sciences, SRHU Jolly Grant, Dehradun. Records of the patients with Hepatitis A and Hepatitis E co-infection were retrieved and analyzed.Results: Out of total 125 patients of acute viral hepatitis, 13 patients had HAV and HEV co-infection. 100% of the patients with co-infection presented with complaints of fever and jaundice, followed by 76.92% with vomiting, 69.23% with pruritis, 61.53% with pain in abdomen and 23.07% with altered sensorium. Mean Bilirubin, ALT, AST were 8.69'7.27 mg/dl, 2030.69'1726.93IU/L and 1880.07'1881.11IU/L respectively. Average duration of stay was 8.2 days. Encephalopathy was seen in 2 patients. However, no mortality was reported.Conclusions: Co-infection of HAV and HEV is not rare in pediatric age group. Knowledge about this will be of immense help for planning of future vaccination strategies and for better sanitation program in developing countries like India.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Himalayan Institute of Medical Sciences, SRHU, Jolly Grant, Dehradun, Uttarakhand, Indiaen_US
dc.identifier.citationHanda Shikha, Wasim Sanober, Kalra B. P., Rawat Anil, Chandar Vipan, Gupta Alpa. Clinico-epidemiological profile of hepatitis A virus and hepatitis E virus co-infection in pediatric age group: a hospital based retrospective study. International Journal of Contemporary Pediatrics. 2019 Mar; 6(2): 588-592en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203983
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20190692en_US
dc.subjectCo-infectionen_US
dc.subjectHepatitis Aen_US
dc.subjectHepatitis Een_US
dc.subjectPublic healthen_US
dc.titleClinico-epidemiological profile of hepatitis A virus and hepatitis E virus co-infection in pediatric age group: a hospital based retrospective studyen_US
dc.typeJournal Articleen_US
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