Incidence of adenomatous hyperplasia in postmortem cirrhotic livers and study of cellular proliferative indices by light microscopy.

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dc.contributor.authorVaiphei, Ken_US
dc.contributor.authorGhosh, U Ken_US
dc.contributor.authorVasishta, R Ken_US
dc.date.accessioned1999-01-04en_US
dc.date.accessioned2009-05-29T03:11:29Z
dc.date.available1999-01-04en_US
dc.date.available2009-05-29T03:11:29Z
dc.date.issued1999-01-04en_US
dc.description.abstractBACKGROUND: Adenomatous hyperplasia (AH) or dysplastic nodule in the liver is considered a preneoplastic lesion. A wide range in its incidence has been reported. AIMS: To study the incidence of AH nodules in autopsy cirrhotic livers and to carry out a comparative study of the cellular proliferative indices. MATERIALS: Retrospective study of 150 cases with cirrhosis of variable etiology at autopsy, over a 15-year period. METHODS: We identified AH on gross examination and studied the morphology. We compared cellular proliferative indices in AH nodules with other liver nodules by using PCNA monoclonal antibody and AgNOR. RESULTS: Alcohol was the commonest etiology (30%), followed by HBsAg positivity (38%). Most patients belonged to the 30-60 years age group, with male predominance. Sixty of the 150 livers showed AH nodules; there were one to four nodules, measuring 6 mm to 50 mm, per liver. 115/122 AH nodules were studied. Ordinary AH (OAH) was seen in 104 and atypical AH (AAH) in 11, with malignant focus (MF) in four. Associated hepatocellular carcinoma (HCC) was seen in 7 cases. A gradual increase in the proliferative indices from surrounding regenerating nodules (SRN) and OAH to AAH to AAH with MF to HCC was observed. In addition, AAH also showed relatively less reticulin fibers. CONCLUSION: The incidence of AH was 40%. In addition to the cellular proliferative indices, relatively less reticulin fibers could be a distinguishing feature for AAH from SRN, OAH and HCC.en_US
dc.description.affiliationDepartment of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh.en_US
dc.identifier.citationVaiphei K, Ghosh UK, Vasishta RK. Incidence of adenomatous hyperplasia in postmortem cirrhotic livers and study of cellular proliferative indices by light microscopy. Indian Journal of Gastroenterology. 1999 Jan-Mar; 18(1): 7-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65044
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdenoma --pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAutopsy --methodsen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B Surface Antigens --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperplasiaen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshLiver Cirrhosis --pathologyen_US
dc.subject.meshLiver Neoplasms --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNucleolus Organizer Regionen_US
dc.subject.meshProliferating Cell Nuclear Antigen --analysisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSilver Stainingen_US
dc.titleIncidence of adenomatous hyperplasia in postmortem cirrhotic livers and study of cellular proliferative indices by light microscopy.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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