Evolution of Biomarkers for Frailty over the Last Decade : A Literature Review

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dc.contributor.authorGalhotra, Anishaen_US
dc.contributor.authorGupta, Monicaen_US
dc.contributor.authorLehl, Sarabmeet, Singhen_US
dc.contributor.authorGalhotra, Arnaven_US
dc.contributor.authorSood, Dhritien_US
dc.contributor.authorGauba, Ankiten_US
dc.date.accessioned2023-06-17T08:34:51Z
dc.date.available2023-06-17T08:34:51Z
dc.date.issued2022-08
dc.description.abstractAging is a Complex Physiological Process which involves remodeling of cellular components and processes, decline of functional reserve, adaptation of the body to these changes and finally senescence. An important concept in ageing physiology is Frailty which is a physiological, age-related condition characterized by a decrease in functional reserve across multiple organ systems. The phenotype of physical frailty has five components, that is, slowness, weakness, low physical activity level, unintentional weight loss and exhaustion It is crucial to mention “Inflammaging”, a term that signifies the development of an age-related inflammation in the body wherein there is an increase in acute phase reactants and pro-inflammatory cytokines contributing independently to the pathogenesis of frailty. Inflammaging has been proposed to be associated with frailty and many studies suggest the existence of a relationship between age-related Frailty and inflammatory Biomarkers. The aim of this review is to study the evolution of our understanding of the role of inflammatory markers in development of Frailty in the older population.en_US
dc.identifier.affiliationsMBBS Student, Government Medical College and Hospital, Sector 32, Chandigarh 160030en_US
dc.identifier.affiliationsMD, DNB (Medicine), Professor, Department of General Medicine, Government Medical College and Hospital, Sector 32, Chandigarh 160030 and Corresponding Authoren_US
dc.identifier.affiliationsMD, Professor, Department of General Medicine, Government Medical College and Hospital, Sector 32, Chandigarh 160030en_US
dc.identifier.affiliationsMBBS student, Dayanand Medical College and Hospital, Ludhiana 141001en_US
dc.identifier.citationGalhotra Anisha, Gupta Monica, Lehl Sarabmeet Singh, Galhotra Arnav, Sood Dhriti, Gauba Ankit. Evolution of Biomarkers for Frailty over the Last Decade : A Literature Review. Journal of The Indian Medical Association. 2022 Aug; 120(8): 59-64en_US
dc.identifier.issn0019-5847
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216599
dc.languageenen_US
dc.publisherIndian Medical Associationen_US
dc.relation.issuenumber8en_US
dc.relation.volume120en_US
dc.source.urionlinejima.com/read_journals.php?article=1002en_US
dc.subjectFrailtyen_US
dc.subjectBiomarkersen_US
dc.subjectInflammationen_US
dc.subjectAgingen_US
dc.titleEvolution of Biomarkers for Frailty over the Last Decade : A Literature Reviewen_US
dc.typeJournal Articleen_US
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