Combined effect of zinc oxide nano particle incorporated chitosan for better antimicrobial activity towards wound healing

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dc.contributor.authorVisnuvinayagam, S.en_US
dc.contributor.authorMurthy, L.N.en_US
dc.contributor.authorJeyakumari, A.en_US
dc.contributor.authorParvathy, U.en_US
dc.contributor.authorAnandan, R.en_US
dc.contributor.authorSivaraman, G.K.en_US
dc.contributor.authorRavishankar, C.N.en_US
dc.date.accessioned2020-11-18T10:16:18Z
dc.date.available2020-11-18T10:16:18Z
dc.date.issued2019-07
dc.description.abstractAim: The aim of the present study was to characterize the zinc oxide nano particle incorporated Chitosan (ZnO-NP-CS) and its antimicrobial activity. Methodology: Zinc oxide nanoparticles (ZnO-NP) were prepared by sol-gel method and Minimum Inhibitory Concentration (MIC), Minimum bactericidal Concentration (MBC) and agar well diffusion method was used for the assessment of antibacterial activity of ZnO-NP and ZnO-NP-CS as well. Results: In UV–spectroscopy, blue shift in wavelength (~365 nm) corresponding to bulk ZnO particles (~385 nm) indicates the nano size. In SEM image, ZnO-NP appeared as nano flake shape and ZnO-NP treated Methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa (PA) bacteria illustrates leakage of intracellular content, fusion and shrinkage of bacteria, respectively. The MIC of ZnO-NP for most of food pathogens were between 0.01 to 0.1mg. Lower MIC was observed for Vibrio cholerae and Listeria monocytogenes; higher MIC was observed for Bacillus cereus and Pseudomonas aeruginosa. In antibiogram assay, the zone of inhibition of ZnO-NP-CS was equal to commercial antibiotics against Multiple Drug Resistant bacteria. Interpretation: The combined effect of ZnO-NP and chitosan is better than the individual component, i.e., around 5–15 mm wider zone of inhibition than chitosan. ZnO-NP-CS can be a suitable alternative for the treatment of wound infected by multiple drug resistant bacteriaen_US
dc.identifier.affiliationsMFB Division, ICAR- CIFT,Cochin-682 029, Indiaen_US
dc.identifier.affiliationsICAR-Mumbai Research Centre of CIFT, Vashi- 400 703, Indiaen_US
dc.identifier.affiliationsICAR-Mumbai Research Centre of CIFT, Vashi- 400 703, Indiaen_US
dc.identifier.affiliationsFish Processing Division, ICAR- CIFT, Cochin-682 029, Indiaen_US
dc.identifier.affiliationsBiochemistry and Nutrition Division, ICAR- CIFT, Cochin-682 029, Indiaen_US
dc.identifier.affiliationsMFB Division, ICAR- CIFT,Cochin-682 029, Indiaen_US
dc.identifier.affiliationsICAR- CIFT, Cochin-682 029, Indiaen_US
dc.identifier.citationVisnuvinayagam S., Murthy L.N., Jeyakumari A., Parvathy U., Anandan R., Sivaraman G.K., Ravishankar C.N.. Combined effect of zinc oxide nano particle incorporated chitosan for better antimicrobial activity towards wound healing. Journal of Environmental Biology . 2019 Jul; 40(4): 691-697en_US
dc.identifier.issn0254-8704
dc.identifier.issn2394-0379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214609
dc.languageenen_US
dc.publisherTriveni Enterprisesen_US
dc.relation.issuenumber4en_US
dc.relation.volume40en_US
dc.source.urihttps://www.jeb.co.in/journal_issues/201907_jul19/paper_16.pdfen_US
dc.subjectAntibiogramen_US
dc.subjectChitosanen_US
dc.subjectMRSAen_US
dc.subjectZinc oxide nanoparticlesen_US
dc.titleCombined effect of zinc oxide nano particle incorporated chitosan for better antimicrobial activity towards wound healingen_US
dc.typeJournal Articleen_US
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