Doxycycline prophylaxis for experimental leptospira infection in non-human primates and hamsters.

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dc.contributor.authorElwell, M Ren_US
dc.contributor.authorWard, G Sen_US
dc.contributor.authorHansukjariya, Pen_US
dc.contributor.authorTingpalapong, Men_US
dc.date.accessioned2009-05-27T16:34:59Z
dc.date.available2009-05-27T16:34:59Z
dc.date.issued1985-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractDoxycycline was effective as a chemoprophylactic agent for experimental Leptospira infection in non-human primates and hamsters. Monkeys injected intraperitoneally with Leptospira bataviae, and receiving only diluent as treatment developed a leptospiremia during the first week and later leptospires were cultured from the cerebrospinal fluid and urine. Monkeys treated daily with oral doxycycline for 10 days beginning one day before infection had a shortened period of detectable leptospiremia, and organisms were never detected in the cerebrospinal fluid or urine. Even an oral dose of doxycycline 2 hours before infection and on day 7 prevented the later infection of the cerebrospinal fluid and urine. In hamsters, doxycycline treatment prevented deaths from acute Leptospira infection and when hamsters were treated daily for 4 or more days, renal infection was prevented. The results of animal studies, the susceptibility of LC0475 and the five other isolates to doxycycline in vitro, and lack of evidence for antibiotic resistance in culture suggests this antibiotic may be useful as a prophylactic drug for high risk groups and an effective treatment for leptospirosis in Thailand.en_US
dc.identifier.citationElwell MR, Ward GS, Hansukjariya P, Tingpalapong M. Doxycycline prophylaxis for experimental leptospira infection in non-human primates and hamsters. The Southeast Asian Journal of Tropical Medicine and Public Health. 1985 Jun; 16(2): 268-73en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35543
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDoxycycline --pharmacologyen_US
dc.subject.meshLeptospira interrogans --drug effectsen_US
dc.subject.meshMacaca mulattaen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWeil Disease --prevention & controlen_US
dc.titleDoxycycline prophylaxis for experimental leptospira infection in non-human primates and hamsters.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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