Cerebral malaria in Indian adults: a prospective study of 441 patients from Bikaner, north-west India.

dc.contributor.authorKochar, D Ken_US
dc.contributor.authorShubhakaran,en_US
dc.contributor.authorKumawat, B Len_US
dc.contributor.authorKochar, S Ken_US
dc.contributor.authorHalwai, Men_US
dc.contributor.authorMakkar, R Ken_US
dc.contributor.authorJoshi, Aen_US
dc.contributor.authorThanvi, Induen_US
dc.date.accessioned2002-02-01en_US
dc.date.accessioned2009-05-30T20:45:40Z
dc.date.available2002-02-01en_US
dc.date.available2009-05-30T20:45:40Z
dc.date.issued2002-02-01en_US
dc.description.abstractAIMS OF THE STUDY: As per WHO (1993) the assessment and analysis of local problems and an appropriate epidemiological information system is an essential part of a control programme before embarking any control activity. METHODOLOGY: Four hundred and fourty one (441) adults of strictly defined admitted cerebral malaria patients were studied. Detailed clinical/neurological examination was done at the time of admission, daily thereafter, at the time of regaining consciousness, at the time of discharge and at weekly intervals in those having neurological sequelae. All patients were treated by i.v./oral quinine and specific syndromes were managed according to WHO guidelines. RESULTS: Apart from fever and unconsciousness in all the patients, other features were convulsion (21.31%), neck rigidity (19%), psychosis (5.21%), conjugate deviation of eyes (2.26%), extrapyramidal rigidity (2.25%), trismus (1.31%), decorticate rigidity (1.13%) and decerebrate rigidity (0.90%). One hundred forty five (32.87%) patients expired and mortality was highest in pregnant ladies (39.28%). The important neurological sequelae in survivors were psychosis in 15 (5.06%), cerebellar ataxia in 14 (4.72%), hemiplegia in five (1.68%), extrapyramidal rigidity (EPR) in four (1.35%), peripheral neuropathy in three (1.01%), EPR with trismus in one (0.33%) and isolated sixth nerve palsy in one (0.33%) patients and all showed complete recovery in further follow up. CONCLUSION: The important observations of this study were stormy presentation, increased incidence of haemoglobinuria and jaundice, presence of neck rigidity, no prognostic relation to fundus abnormalities and high incidence of cerebellar ataxia and psychosis as neurological sequelae in survivors. Knowledge of self-limiting course of neurological sequelae may be helpful in reducing economic strain of expensive investigations and treatment.en_US
dc.description.affiliationDepartment of Medicine, SP Medical College, Bikaner.en_US
dc.identifier.citationKochar DK, Shubhakaran , Kumawat BL, Kochar SK, Halwai M, Makkar RK, Joshi A, Thanvi I. Cerebral malaria in Indian adults: a prospective study of 441 patients from Bikaner, north-west India. Journal of the Association of Physicians of India. 2002 Feb; 50(): 234-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/87997
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshChilden_US
dc.subject.meshData Interpretation, Statisticalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMalaria, Cerebral --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Infectious --epidemiologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSex Factorsen_US
dc.titleCerebral malaria in Indian adults: a prospective study of 441 patients from Bikaner, north-west India.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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