Fulminant hepatic failure: etiology, viral markers and outcome.

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dc.contributor.authorBendre, S Ven_US
dc.contributor.authorBavdekar, A Ren_US
dc.contributor.authorBhave, S Aen_US
dc.contributor.authorPandit, A Nen_US
dc.contributor.authorChitambar, S Den_US
dc.contributor.authorArankalle, V Aen_US
dc.date.accessioned1999-11-04en_US
dc.date.accessioned2009-05-27T05:31:39Z
dc.date.available1999-11-04en_US
dc.date.available2009-05-27T05:31:39Z
dc.date.issued1999-11-04en_US
dc.description.abstractOBJECTIVE: To investigate the etiology and outcome of fulminant hepatic failure (FHF) in children. SETTING: Hospital based descriptive. METHODS: 36 children (22 males and 14 females) presenting with FHF over a period of one year were investigated. The ages ranged from 1.5 to 9 years. FHF was defined as occurrence of encephalopathy within eight weeks of onset of jaundice with no evidence of pre-existing liver disease. Detailed history, clinical examination, routine biochemical parameters and relevant diagnostic tests were carried out. Viral markers studied were anti HAV-IgM, HBsAg, anti HBc-IgM, anti-HCV and anti HEV-IgM. RESULTS: A viral etiology could be established in 22 children (61.1%). Hepatitis A (n = 12), Hepatitis B (n = 3), Hepatitis A and B (n = 2), and Hepatitis A and E (n = 4). Two children had enteric fever (1 with associated HEV), 2 children had Wilson's disease, 1 child had Indian Childhood Cirrhosis (ICC) and 2 children had drug induced hepatitis. Etiological diagnosis was not possible in 8 children (22%). Fourteen children (39%) died. Poor outcome was associated with spontaneous bleeding, raised prothrombin time, lower transaminases and higher bilirubin on admission. CONCLUSION: Viral hepatitis is the commonest cause of FHF in children. HAV alone or in combination is responsible for upto 50% of all FHF in children. Chronic liver disease can also present as FHF. Etiological diagnosis is not possible to upto one-fourth of all cases.en_US
dc.description.affiliationDepartment of Pediatrics, K.E.M. Hospital, Pune 411 011, India.en_US
dc.identifier.citationBendre SV, Bavdekar AR, Bhave SA, Pandit AN, Chitambar SD, Arankalle VA. Fulminant hepatic failure: etiology, viral markers and outcome. Indian Pediatrics. 1999 Nov; 36(11): 1107-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/11477
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHepatic Encephalopathy --etiologyen_US
dc.subject.meshHepatitis A Virus, Human --immunologyen_US
dc.subject.meshHepatitis B Core Antigens --blooden_US
dc.subject.meshHepatitis B Surface Antigens --blooden_US
dc.subject.meshHepatitis C Antibodies --immunologyen_US
dc.subject.meshHepatitis Delta Virus --immunologyen_US
dc.subject.meshHepatitis E virus --immunologyen_US
dc.subject.meshHepatitis, Chronic, Drug-Induced --complicationsen_US
dc.subject.meshHepatitis, Viral, Human --complicationsen_US
dc.subject.meshHepatolenticular Degeneration --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshJaundice --etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshTyphoid Fever --complicationsen_US
dc.titleFulminant hepatic failure: etiology, viral markers and outcome.en_US
dc.typeJournal Articleen_US
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