Clinicopathologic study of Kikuchi's disease in children in a tertiary hospital in South India

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dc.contributor.authorPunnen, Anuen_US
dc.contributor.authorKanagalakshmien_US
dc.contributor.authorManipadam, Marie Thereseen_US
dc.contributor.authorVerghese, Valsan Philipen_US
dc.contributor.authorMathew, Leni Graceen_US
dc.contributor.authorKumar, Sathishen_US
dc.date.accessioned2020-09-24T07:43:18Z
dc.date.available2020-09-24T07:43:18Z
dc.date.issued2019-03
dc.description.abstractBackground: The aim of this study was to evaluate the clinical and laboratory characteristics, treatment modalities and outcome of children with Kikuchi's disease.Methods: A retrospective cross-sectional study was conducted among all children, histopathologically diagnosed with KFD.' Clinical, laboratory data and treatment outcomes were analysed.Results: During the study period, 53 children histopathologically confirmed as KFD were enrolled in the study. There were 36 males and 17 females. The lymph node involvements were mostly cervical with bilateral predisposition (63.5%), firm (88%), matted (30.8%) and tenderness (38.5%). Fever, headache, vomiting, chills, myalgia and rash were other common presentations other than cervical lymphadenopathy. The associated laboratory findings include anemia (71.2%), leukopenia especially lymphopenia (31.4%), monocytosis (21.6%), thrombocytopenia (16.3%), elevated CRP (53.1%), ESR (83.7%), LDH (100%) and elevated liver enzymes. Most of the children were managed conservatively (49.1%). Corticosteroids were administered for (22.6 %) of patients. Recurrence occurred in 4 children (7.5 %) and 13 children (24.5%) had other associated diseases.Conclusions: KFD should be suspected in well children with febrile cervical lymphadenopathy, especially with leukopenia, monocytosis, and elevated CRP, ESR, LDH, Liver enzymes. KFD in children can have rarely atypical presentations and coexist with other diseases.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.citationPunnen Anu, Kanagalakshmi, Manipadam Marie Therese, Verghese Valsan Philip, Mathew Leni Grace, Kumar Sathish. Clinicopathologic study of Kikuchi's disease in children in a tertiary hospital in South India. International Journal of Contemporary Pediatrics. 2019 Mar; 6(2): 664-669en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204000
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20190708en_US
dc.subjectC- reactive proteinen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.subjectKikuchi-Fujimoto diseaseen_US
dc.subjectLactate dehydrogenaseen_US
dc.subjectSystemic lupus erythematosusen_US
dc.titleClinicopathologic study of Kikuchi's disease in children in a tertiary hospital in South Indiaen_US
dc.typeJournal Articleen_US
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