Clinico-Hematological Profile and Management of Children With Non-Transfusion Dependent Thalassemia (NTDT) at a Pediatric Center in Northern India

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dc.contributor.authorParakh, Nupuren_US
dc.contributor.authorKhan, Afreenen_US
dc.contributor.authorSharma, Sunitaen_US
dc.contributor.authorChandra, Jagdishen_US
dc.date.accessioned2023-08-25T06:40:00Z
dc.date.available2023-08-25T06:40:00Z
dc.date.issued2023-08
dc.description.abstractObjective: To study the clinico-hematological profile, complications, and management of children with non-transfusion dependent thalassemia (NTDT) in northern India. Method: We retrieved and analyzed the data of 69 children with NTDT diagnosed between January, 2006 to December, 2018, aged under 18 years from our unit’s records. Result: The participants mean (SD) age was 4.4 (3.1) years, and they presented with anemia (29%), jaundice (13%), hemolytic facies (13%), splenomegaly (87%), thromboembolism (2.9%) and pathological short stature (28.5%). The most common cause of NTDT was ?-thalassemia (45%), followed by either compound-heterozygous or homozygous for E?-thalassemia mutation. The most frequent single genotype observed was compound heterozygous for IVS1-5 (G>C) and codon 26 (G>A). The mean (SD) follow-up duration was 3.5 (2.4) years. On follow-up, 27 children (%) remained transfusion free, and 30 (%) needed occasional transfusions. 63% of patients initially presenting with pathological short stature showed improvement in growth. Amongst children older than 10 years (n=20), subclinical hypothyroidism was detected in 6 children and impaired glucose tolerance test in 1 child. Conclusion: Eß-thalassemia was the commonest cause of NTDT in this population.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Kalawati Saran Children’s Hospital, New Delhien_US
dc.identifier.affiliationsDepartment of Pediatrics, Hamdard Institute of Medical Sciences and Research Institute, New Delhien_US
dc.identifier.affiliationsDepartment of Pathology, Kalawati Saran Children’s Hospital, New Delhi.en_US
dc.identifier.citationParakh Nupur, Khan Afreen, Sharma Sunita, Chandra Jagdish. Clinico-Hematological Profile and Management of Children With Non-Transfusion Dependent Thalassemia (NTDT) at a Pediatric Center in Northern India. Indian Pediatrics. 2023 Aug; 60(8): 644-647en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225450
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber8en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/aug2023/644.pdfen_US
dc.subjectChelationen_US
dc.subjectIron overloaden_US
dc.subjectThrombosis.en_US
dc.titleClinico-Hematological Profile and Management of Children With Non-Transfusion Dependent Thalassemia (NTDT) at a Pediatric Center in Northern Indiaen_US
dc.typeJournal Articleen_US
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