Attenuated form of Evans syndrome among pediatric ITP patients.

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dc.contributor.authorDash, Sumitraen_US
dc.contributor.authorMarwaha, Ramen_US
dc.contributor.authorTrehan, Amitaen_US
dc.date.accessioned2006-04-03en_US
dc.date.accessioned2009-05-27T06:00:08Z
dc.date.available2006-04-03en_US
dc.date.available2009-05-27T06:00:08Z
dc.date.issued2006-04-03en_US
dc.description.abstractLong term follow up of adult patients with immune thrombocytopenic purpura (ITP) have shown evolvement of secondary autoimmune diseases such as SLE, Evans syndrome, autoimmune neutropenia, Graves disease etc. We studied 30 cases of pediatric ITP patients for evidence of hemolysis to assess the possibility of Evans like syndrome. Measurement of free serum haptoglobin, a sensitive indicator of red cell destruction was used after careful exclusion of micro angiopathic hemolysis, SLE or overt Evans Syndrome. Results showed abnormally low level of free serum haptoglobin in 11 of the 30 (36.7%) patients compared to that in 20 age matched controls (P < 0.001) as an evidence of hemolysis. Our data in pediatric patients is similar to that reported in adult ITP cases and support the observation of Evans made 50 years ago that there is a spectrum like relationship between primary thrombocytopenia and hemolytic anemia. Thus the concept of attenuated form of Evans syndrome could be considered, in group of patients with ITP in pediatric age group.en_US
dc.description.affiliationDepartment of Hematolog, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India. sumitradash2001@yahoo.comen_US
dc.identifier.citationDash S, Marwaha R, Trehan A. Attenuated form of Evans syndrome among pediatric ITP patients. Indian Pediatrics. 2006 Apr; 43(4): 340-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/14384
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnemia, Hemolytic, Autoimmune --blooden_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshBone Marrow Cells --metabolismen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaptoglobins --metabolismen_US
dc.subject.meshHemoglobins --metabolismen_US
dc.subject.meshHemolysisen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMegakaryocytes --metabolismen_US
dc.subject.meshPlatelet Counten_US
dc.subject.meshPurpura, Thrombocytopenic, Idiopathic --blooden_US
dc.subject.meshSyndromeen_US
dc.titleAttenuated form of Evans syndrome among pediatric ITP patients.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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