Biochemical markers as predictors of dengue severity

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dc.contributor.authorGupta, Vishal Kumaren_US
dc.contributor.authorGiri, Richaen_US
dc.contributor.authorAgrawal, Saurabhen_US
dc.date.accessioned2023-08-28T06:35:36Z
dc.date.available2023-08-28T06:35:36Z
dc.date.issued2022-02
dc.description.abstractBackground:The objective of this study was to evaluate biochemical markers as predictors of dengue severity clinical outcome, bleeding severity, capillary leakage, supportive therapy requirement and duration of hospital stay.Methods:In this observational study Patients from age more than 15 years with history of acute febrile illness Total 263 confirmed cases (based on the WHO criteria) of DF were included in this study, who have been admitted in our hospital. We measured levels of CK, LDH, AST and ALT with modified liquid-UV tests; semi-quantitative levels of CRP with a colorimetric rapid test; levels of albumin with colorimetric tests; and lipid profiles [cholesterol, triglycerides, Low-density lipoprotein (LDL) and High-density lipo-protein (HDL)] with a liquid-color test. Positive control human samples were included in all tests.Results:We found that TG and LDL-C levels were significantly lower in dengue-positive patients compared to dengue-negative patients, and that LDL-C levels showed greater decreases and thus appeared to drive the reduction in total cholesterol. LDH, CPK, AST and ALT were significantly raised in DSS in compared to DF and other febrile illness. We found that lower total serum cholesterol and LDL-C levels at presentation were associated with subsequent development of DHF/DSS.Conclusions:Assessment of lymphocyte, platelet counts, levels of LDL, TG, CPK, LDH, levels of AST and ALT are very significant and easily available and low-cost biochemical markers for prediction of dengue infection severity.en_US
dc.identifier.affiliationsDepartment ofMedicine, GSVM Medical College Kanpur, Uttar Pradesh,Indiaen_US
dc.identifier.citationGupta Vishal Kumar, Giri Richa, Agrawal Saurabh. Biochemical markers as predictors of dengue severity. International Journal of Advances in Medicine. 2022 Feb; 9(2): 89-94en_US
dc.identifier.issn2349-3933
dc.identifier.issn2349-3925
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225706
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20220114en_US
dc.subjectDengueen_US
dc.subjectBiochemical markeren_US
dc.subjectPredictors of dengue severityen_US
dc.titleBiochemical markers as predictors of dengue severityen_US
dc.typeJournal Articleen_US
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