A Clinicoepidemiological Study of Pemphigus in India.
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Date
2015-06
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Abstract
Introduction: Pemphigus is a group of autoimmune
bullous disorder affecting skin and mucosa. There are
reports of some factors that can provoke the disease in
genetically predisposed individuals and some have a
protective effect. Aims and Objectives: To study the
clinical features of pemphigus and possible epidemiological
risk factors. Materials and Methods: Hundred cases with
clinical diagnosis of pemphigus and equal number of
controls were selected for the study. The clinical features
of the disease and possible epidemiological risk factors
were studied and compared with controls. Routine blood
tests were also advised. Observations: There were 78
cases of pemphigus vulgaris (PV), 21 of foliaceous (PF)
and 1 of erythematosus (PE). Ratio of male: female was
0.92:1. Mean age of cases was 40.905 ± 14.011 and of
controls 42.64 ± 12.756. History of (h/o) exposure to
pesticides in fields, intake of food containing garlic,
number of pregnancies and use of cosmetics (Kajal) were
significantly high in cases whereas smoking, tobacco
chewing, herpes infection and mental stress were high in
controls. Exposure to fertilizers, intake of alcohol and oral
contraceptives were equal in both. Conclusion: Pemphigus
had slight female preponderance in lower socioeconomic
strata of rural areas. Exposure to pesticides, garlic intake,
use of cosmetics and higher number of pregnancies may
be predisposing where as smoking or tobacco chewing
was not. Avoiding such risk factors may be helpful in
prevention or fast recovery of pemphigus.
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Keywords
pemphigus, clinical, epidemiologica, risk factors
Citation
Sharma Lata, Deepak V. A Clinicoepidemiological Study of Pemphigus in India. Indian Medical Gazette. 2015 Jun; 149(6): 219- 224.