Nitric oxide derivative in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis.

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dc.contributor.authorBehera, Den_US
dc.contributor.authorKaur, Sen_US
dc.contributor.authorSathyanarayana, Gen_US
dc.contributor.authorBhatnagar, Aen_US
dc.contributor.authorMajumdar, Sen_US
dc.date.accessioned2002-01-16en_US
dc.date.accessioned2009-05-27T10:19:06Z
dc.date.available2002-01-16en_US
dc.date.available2009-05-27T10:19:06Z
dc.date.issued2002-01-16en_US
dc.description.abstractIdiopathic pulmonary fibrosis is a chronic inflammatory disorder of unknown aetiology with a number of inflammatory cells playing a role in its pathogenesis. In this study, we have attempted to find out the possible role of nitric oxide in its pathogenesis by way of measuring the nitrite and nitrate levels in the bronchoalveolar lavage fluid. Ten patients of histologically proved idiopathic pulmonary fibrosis and 10 controls (5 with normal chest skiagrams and 5 with sarcoidosis) were included in the study Bronchoalveolar lavage was carried out in these cases. The levels of nitrates and nitrites were increased in cases of idiopathic pulmonary fibrosis (0.77+/- 0.36 and 8.93 +/- 2.63 nmol/mg of protein) compared to those in controls (0.38 +/- 0.06 and 3.80 +/- 1.11, respectively for sarcoidosis patients); (0.39 +/- 0.13 and 6.56 +/- 1.61 for subjects with normal chest skiagrams). These differences were statistically significant (p < 0.05 to 0.01). These findings suggest a possible role of nitric oxide in the pathogenesis of idiopathic pulmonary fibrosis.en_US
dc.description.affiliationDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dbehera@sancharnet.inen_US
dc.identifier.citationBehera D, Kaur S, Sathyanarayana G, Bhatnagar A, Majumdar S. Nitric oxide derivative in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis. The Indian Journal of Chest Diseases & Allied Sciences. 2002 Jan-Mar; 44(1): 21-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/29689
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/iae/iaem.shtmlen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBronchoalveolar Lavage Fluid --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNitric Oxide --analogs & derivativesen_US
dc.subject.meshPulmonary Fibrosis --physiopathologyen_US
dc.titleNitric oxide derivative in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis.en_US
dc.typeJournal Articleen_US
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