Does I-131-MIBG underestimate skeletal disease burden in neuroblastoma?
dc.contributor.author | Barai, S | en_US |
dc.contributor.author | Bandopadhayaya, G P | en_US |
dc.contributor.author | Malhotra, A | en_US |
dc.contributor.author | Agarwal, S | en_US |
dc.contributor.author | Kumar, R | en_US |
dc.contributor.author | Dhanapathi, H | en_US |
dc.date.accessioned | 2004-10-30 | en_US |
dc.date.accessioned | 2009-06-02T10:12:44Z | |
dc.date.available | 2004-10-30 | en_US |
dc.date.available | 2009-06-02T10:12:44Z | |
dc.date.issued | 2004-10-30 | en_US |
dc.description.abstract | BACKGROUND: Controversy persists as to the need for both MIBG and bone scanning in routine evaluation of neuroblastoma. AIM: To compare the efficacy of I-131- metaiodobenzylguanidine (MIBG) scan against that of conventional Tc99m- methylene diphosphonate (MDP) bone scan for the detection of skeletal deposition of neuroblastoma. METHODS AND MATERIAL: The study included 57 patients (36 boys, 21 girls: age range 1-14 years) of neuroblastoma who underwent both bone scan with Tc99m-MDP and I-131-MIBG scan within 15 days of each other at presentation and during follow-up. RESULTS: At presentation 11(19.2%) patients had evidence of skeletal metastases on MDP scan against 7 patients who showed bony secondaries on MIBG scan. Of the 7 patients, with positive MIBG and MDP scans, MDP scan detected 11 sites whereas MIBG scan detected 7 sites. On follow-up study, 3 patients with initial abnormal MDP scan but normal MIBG scan, developed skeletal metastases detectable on MIBG scan, whereas 3 of the 46 patients who had normal MDP and MIBG scan at presentation; developed skeletal metastases detectable on MDP scan. MIBG scan was concordant in 2 of them but was normal in the third patient. CONCLUSION: I-131-MIBG underestimates skeletal disease burden in neuroblastoma. Therefore, Tc99m-MDP bone scan should remain a part of routine assessment of patients with neuroblastoma. | en_US |
dc.description.affiliation | Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. danzig@rediffmail.com | en_US |
dc.identifier.citation | Barai S, Bandopadhayaya GP, Malhotra A, Agarwal S, Kumar R, Dhanapathi H. Does I-131-MIBG underestimate skeletal disease burden in neuroblastoma? Journal of Postgraduate Medicine. 2004 Oct-Dec; 50(4): 257-60; discussion 260-1 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/115362 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.jpgmonline.com | en_US |
dc.subject.mesh | 3-Iodobenzylguanidine --diagnostic use | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Bone Neoplasms --radionuclide imaging | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Child, Preschool | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infant | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neuroblastoma --radionuclide imaging | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.subject.mesh | Radiopharmaceuticals --diagnostic use | en_US |
dc.subject.mesh | Technetium Tc 99m Medronate --diagnostic use | en_US |
dc.title | Does I-131-MIBG underestimate skeletal disease burden in neuroblastoma? | en_US |
dc.type | Comparative Study | en_US |
dc.type | Journal Article | en_US |
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