Sedative action of some substituted benzylamides.

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dc.contributor.authorSethi, O Pen_US
dc.contributor.authorGupta, M Ven_US
dc.contributor.authorBhatia, O Sen_US
dc.contributor.authorDerasari, H Ren_US
dc.date.accessioned1977-01-01en_US
dc.date.accessioned2009-06-01T07:57:59Z
dc.date.available1977-01-01en_US
dc.date.available2009-06-01T07:57:59Z
dc.date.issued1977-01-01en_US
dc.description.abstractSubstituted benzylamide derivatives of amino acylamide (compound A,B,C, & D) were found to be less potent local anaesthetics than lignocaine and procaine. However, the four compounds exhibited sedation without ptosis and reduced spontaneous locomotor activity better than methaqualone. Compound A alone antagonised methylamphetamine induced hypermotor activity. The test compounds potentiated hexobarbitone induced hypnosis. Three compounds antagonised calcium induced stoppage of isolated heart of frog. Except compound C all caused a transitory fall of blood pressure in dog which was not blocked either by atropine or propranolol. These compounds showed neuromuscular blockade and possessed slight analgesic activity but were devoid of anticonvulsant and tranquillizing activity. LD 50 values were calculated to be 164.1 +/- 23.0, 229.1 +/- 51.0, 181.6 +/- 28.18 and 416+/-38.2 mg/kg for compounds A,B,C & D respectively.en_US
dc.identifier.citationSethi OP, Gupta MV, Bhatia OS, Derasari HR. Sedative action of some substituted benzylamides. Indian Journal of Physiology and Pharmacology. 1977 Jan-Mar; 21(1): 1-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108557
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAmides --pharmacologyen_US
dc.subject.meshAnesthetics, Localen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnuraen_US
dc.subject.meshBenzyl Compounds --pharmacologyen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshDepression, Chemicalen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshHypnotics and Sedativesen_US
dc.subject.meshIleum --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshMuscle, Smooth --drug effectsen_US
dc.subject.meshMuscles --drug effectsen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.titleSedative action of some substituted benzylamides.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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