A clinicopathologic study of mantle cell lymphoma in a single center study in India.

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dc.contributor.authorGujral, Sen_US
dc.contributor.authorAgarwal, Aen_US
dc.contributor.authorGota, Ven_US
dc.contributor.authorNair, Ren_US
dc.contributor.authorGupta, Sen_US
dc.contributor.authorPai, S Ken_US
dc.contributor.authorSanger, Men_US
dc.contributor.authorShet, Ten_US
dc.contributor.authorSubramanian, P Gen_US
dc.contributor.authorMuckaden, Men_US
dc.contributor.authorLaskar, Sen_US
dc.date.accessioned2008-07-30en_US
dc.date.accessioned2009-05-29T10:50:33Z
dc.date.available2008-07-30en_US
dc.date.available2009-05-29T10:50:33Z
dc.date.issued2008-07-30en_US
dc.description.abstractWe present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.en_US
dc.description.affiliationDepartment of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India. s_gujral@hotmail.comen_US
dc.identifier.citationGujral S, Agarwal A, Gota V, Nair R, Gupta S, Pai SK, Sanger M, Shet T, Subramanian PG, Muckaden M, Laskar S. A clinicopathologic study of mantle cell lymphoma in a single center study in India. Indian Journal of Pathology & Microbiology. 2008 Jul-Sep; 51(3): 315-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/72871
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, CD20 --biosynthesisen_US
dc.subject.meshAntigens, CD43 --biosynthesisen_US
dc.subject.meshAntigens, CD5 --biosynthesisen_US
dc.subject.meshAntineoplastic Agents --therapeutic useen_US
dc.subject.meshBone Marrow --pathologyen_US
dc.subject.meshCyclin D1 --biosynthesisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Tract --pathologyen_US
dc.subject.meshHospitalsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLymphoma, Mantle-Cell --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSurvival Analysisen_US
dc.titleA clinicopathologic study of mantle cell lymphoma in a single center study in India.en_US
dc.typeJournal Articleen_US
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