Ptychodiscus brevis toxin decreases the spontaneous activity of rat right atria involving muscarinic receptors and potassium channels.

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dc.contributor.authorSingh, Jitendra Nen_US
dc.contributor.authorMandal, Maloy Ben_US
dc.contributor.authorDeshpande, Shripad Ben_US
dc.date.accessioned2008-04-10en_US
dc.date.accessioned2009-06-01T05:21:28Z
dc.date.available2008-04-10en_US
dc.date.available2009-06-01T05:21:28Z
dc.date.issued2008-04-10en_US
dc.description.abstractMarine dinoflagellate Ptychodiscus brevis toxin (PbTx), is known to produce toxic effects on cardiovascular system. The present experiments were conducted to evaluate the effect of synthetic phosphorus containing Ptychodiscus brevis toxin on spontaneously beating right atrium in vitro. The PbTx (0.84-84 microM) decreased the rate and force of right atrial contractions in a concentration-dependent manner. Ethanol, a vehicle present in highest concentration of PbTx, had no effect on atrial rate or force of contraction. Pretreatment with atropine blocked the PbTx-induced decrease in atrial rate and force of contraction. The tetraethylammonium, a potassium channel blocker, blocked the PbTx-induced decrease in atrial rate and force, where as, L-type of calcium channel blocker, nifedipine blocked the PbTx-induced force of contraction but not the rate changes. The results indicate that the PbTx decreased the atrial rate and force of contraction via cholinergic receptors involving K+ channel.en_US
dc.description.affiliationDepartment of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005.en_US
dc.identifier.citationSingh JN, Mandal MB, Deshpande SB. Ptychodiscus brevis toxin decreases the spontaneous activity of rat right atria involving muscarinic receptors and potassium channels. Indian Journal of Physiology and Pharmacology. 2008 Apr-Jun; 52(2): 157-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106550
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropine --pharmacologyen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshCyclopentanes --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHeart Atria --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscarinic Antagonists --pharmacologyen_US
dc.subject.meshMyocardial Contraction --drug effectsen_US
dc.subject.meshNifedipine --pharmacologyen_US
dc.subject.meshOrganophosphorus Compounds --pharmacologyen_US
dc.subject.meshPotassium Channel Blockers --pharmacologyen_US
dc.subject.meshPotassium Channels --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Muscarinic --drug effectsen_US
dc.subject.meshTetraethylammonium --pharmacologyen_US
dc.titlePtychodiscus brevis toxin decreases the spontaneous activity of rat right atria involving muscarinic receptors and potassium channels.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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