An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer

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dc.contributor.authorLiu, Taoen_US
dc.contributor.authorLiu, Wen-Zhouen_US
dc.contributor.authorSun, Yuen_US
dc.contributor.authorBi, Xiao-Hanen_US
dc.contributor.authorZhou, Hua-Fuen_US
dc.date.accessioned2020-11-18T10:08:09Z
dc.date.available2020-11-18T10:08:09Z
dc.date.issued2020-09
dc.description.abstractAim of Study: There were many reports published on the relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer in these years. In previous, we conducted a meta-analysis to evaluate the relationship between GSTT1 null/presence gene polymorphism and the risk of lung cancer. This study was conducted to update it. Materials and Methods: The association studies were identified from PubMed and Cochrane Library on March 1, 2016. Results: Sixty-three reports were recruited into this meta-analysis for the association of null genotype of GSTT1 with lung cancer susceptibility, consisting of 21,220 patients with lung cancer and 21,496 controls. There was a marked association between GSTT1 null genotype and lung cancer risk in overall populations and in Asians (overall populations: Odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.07–1.28, P = 0.006; Asians: OR = 1.41, 95% CI: 1.23–1.62, P < 0.00001). However, GSTT1 null genotype was not associated with the risk of lung cancer in Caucasians, Brazilian population, and Africans. Conclusion: GSTT1 null genotype is associated with the lung cancer risk in overall populations and in Asiansen_US
dc.identifier.affiliationsDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Chinaen_US
dc.identifier.citationLiu Tao, Liu Wen-Zhou, Sun Yu, Bi Xiao-Han, Zhou Hua-Fu. An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer. Journal of Cancer Research and Therapeutics. 2020 Sep; 16(4): 718-725en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213692
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/0973-1482.189237en_US
dc.subjectGene polymorphismen_US
dc.subjectglutathione S‑transferase T1en_US
dc.subjectlung canceren_US
dc.subjectupdated meta‑analysisen_US
dc.titleAn updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung canceren_US
dc.typeJournal Articleen_US
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