An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer
dc.contributor.author | Liu, Tao | en_US |
dc.contributor.author | Liu, Wen-Zhou | en_US |
dc.contributor.author | Sun, Yu | en_US |
dc.contributor.author | Bi, Xiao-Han | en_US |
dc.contributor.author | Zhou, Hua-Fu | en_US |
dc.date.accessioned | 2020-11-18T10:08:09Z | |
dc.date.available | 2020-11-18T10:08:09Z | |
dc.date.issued | 2020-09 | |
dc.description.abstract | Aim of Study: There were many reports published on the relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer in these years. In previous, we conducted a meta-analysis to evaluate the relationship between GSTT1 null/presence gene polymorphism and the risk of lung cancer. This study was conducted to update it. Materials and Methods: The association studies were identified from PubMed and Cochrane Library on March 1, 2016. Results: Sixty-three reports were recruited into this meta-analysis for the association of null genotype of GSTT1 with lung cancer susceptibility, consisting of 21,220 patients with lung cancer and 21,496 controls. There was a marked association between GSTT1 null genotype and lung cancer risk in overall populations and in Asians (overall populations: Odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.07–1.28, P = 0.006; Asians: OR = 1.41, 95% CI: 1.23–1.62, P < 0.00001). However, GSTT1 null genotype was not associated with the risk of lung cancer in Caucasians, Brazilian population, and Africans. Conclusion: GSTT1 null genotype is associated with the lung cancer risk in overall populations and in Asians | en_US |
dc.identifier.affiliations | Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | en_US |
dc.identifier.citation | Liu Tao, Liu Wen-Zhou, Sun Yu, Bi Xiao-Han, Zhou Hua-Fu. An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer. Journal of Cancer Research and Therapeutics. 2020 Sep; 16(4): 718-725 | en_US |
dc.identifier.issn | 0973-1482 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/213692 | |
dc.language | en | en_US |
dc.publisher | Wolters Kluwer India Pvt. Ltd. | en_US |
dc.relation.issuenumber | 4 | en_US |
dc.relation.volume | 16 | en_US |
dc.source.uri | https://dx.doi.org//10.4103/0973-1482.189237 | en_US |
dc.subject | Gene polymorphism | en_US |
dc.subject | glutathione S‑transferase T1 | en_US |
dc.subject | lung cancer | en_US |
dc.subject | updated meta‑analysis | en_US |
dc.title | An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer | en_US |
dc.type | Journal Article | en_US |
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