Differentiation of human nasopharyngeal carcinoma xenografts and repression of telomerase activity induced by arsenic trioxide.

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dc.contributor.authorDu, Caiwenen_US
dc.contributor.authorLi, Deruien_US
dc.contributor.authorLin, Yingchengen_US
dc.contributor.authorWu, Mingyaoen_US
dc.date.accessioned2004-03-15en_US
dc.date.accessioned2009-06-03T07:34:42Z
dc.date.available2004-03-15en_US
dc.date.available2009-06-03T07:34:42Z
dc.date.issued2004-03-15en_US
dc.description.abstractBACKGROUND: Arsenic trioxide (As2O3) induced apoptosis and differentiation of acute promyelocytic leukaemia. A few in vivo experimental investigations of its efficacy in solid tumours have been done. This study was designed to explore the differentiation-inducing effect, and the possible mechanisms involved, of As2O3 on human nasopharyngeal carcinoma CSNE-1 xenografts. METHODS: Nasopharyngeal carcinoma cell CSNE-1 was established as a xenograft in nude mice. The tumour-bearing mice were treated with As2O3 at a dose of 5 mg/kg/day. To assess tumour differentiation, tumour growth was observed and histological changes were analysed under light and electron microscopy. Expression of latent membrane protein 1 (LMP1) and cytokeratin 4 (CK4) was determined by immunohistochemistry. A PCR-based telomeric repeat amplification protocol assay (TRAP-ELISA) was used to measure telomerase activity. RESULTS: The xenografts underwent differentiation. LMP 1 of the cells decreased significantly and there was a pronounced decline in telomerase activity. CONCLUSION: As2O3 can inhibit xenograft growth and induce morphological and functional differentiation of CSNE-1 cells. The As2O3-induced differentiation was associated with downregulation of telomerase activity.en_US
dc.description.affiliationShantou University Medical College, Shantou, Guangdong 515031, China.en_US
dc.identifier.citationDu C, Li D, Lin Y, Wu M. Differentiation of human nasopharyngeal carcinoma xenografts and repression of telomerase activity induced by arsenic trioxide. National Medical Journal of India. 2004 Mar-Apr; 17(2): 67-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119810
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshArsenicals --adverse effectsen_US
dc.subject.meshCarcinoma, Squamous Cell --drug therapyen_US
dc.subject.meshCell Differentiation --drug effectsen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLeukemia, Promyelocytic, Acute --drug therapyen_US
dc.subject.meshMiceen_US
dc.subject.meshNasopharyngeal Neoplasms --drug therapyen_US
dc.subject.meshOxides --adverse effectsen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshTelomerase --antagonists & inhibitorsen_US
dc.subject.meshTransplantation, Heterologous --pathologyen_US
dc.titleDifferentiation of human nasopharyngeal carcinoma xenografts and repression of telomerase activity induced by arsenic trioxide.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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