A more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients.

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dc.contributor.authorSnabboon, Thitien_US
dc.contributor.authorSridama, Vitayaen_US
dc.contributor.authorSunthornyothin, Saraten_US
dc.contributor.authorSuwanwalaikorn, Sompongseen_US
dc.contributor.authorVongthavaravat, Varaphonen_US
dc.date.accessioned2009-05-27T19:39:20Z
dc.date.available2009-05-27T19:39:20Z
dc.date.issued2004-09-09en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Thyroid function test is an essential tool in the diagnosis of thyroid dysfunction. To date, it is still controversial which diagnostic algorithm is best applicable to clinically hyperthyroidism patients. OBJECTIVE: To compare various algorithms of thyroid function tests in the diagnosis of hyperthyroidism. METHOD: Patients from the endocrine clinic, King Chulalongkorn Memorial Hospital were investigated for thyroid function tests (T3, T4, FT3, FT4 and TSH). Hyperthyroidism was defined as an elevated either FT3 or FT4 with suppressed TSH. The authors compared the effectiveness in hyperthyroidism diagnosis among algorithms by using sensitivity, specificity, positive predictive value and negative predictive value. RESULTS: Of all 452 patients in the present study, 94.24 percent were women. There were 206 hyperthyroidism, 30 subclinical hyperthyroidism, 1 subclinical hypothyroidism, 8 primary hypothyroidism and 207 normal subjects. The incidence of T3 toxicosis was 16.02% while that of T4 toxicosis was 2.16%. After the effectiveness analysis of these algorithms, FT3 and TSH is the most optimal test with 97.57% sensitivity and 100% specificity. Compared to FT4 and TSH, it gave 83.98% sensitivity and 100% specificity. CONCLUSION: According to the high incidence of T3 toxicosis in the present study, FT3 and TSH should be the initial test for diagnosis of hyperthyroid patients in an outpatient setting and FT4 should be measured subsequently in case of suspected T4 toxicosis.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Patumwan, Bangkok 10330, Thailand.en_US
dc.identifier.citationSnabboon T, Sridama V, Sunthornyothin S, Suwanwalaikorn S, Vongthavaravat V. A more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients. Journal of the Medical Association of Thailand. 2004 Sep; 87 Suppl 2(): S19-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41539
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAlgorithmsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperthyroidism --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.subject.meshThyroid Function Testsen_US
dc.subject.meshThyrotropin --blooden_US
dc.subject.meshThyroxine --blooden_US
dc.subject.meshTriiodothyronine --blooden_US
dc.titleA more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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