Role of macrophages in experimental malaria: VI--Effect of Freund's complete adjuvant in Plasmodium berghei infected mice.

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dc.contributor.authorPillai, C Ren_US
dc.contributor.authorUsha Devi, Cen_US
dc.date.accessioned1999-06-16en_US
dc.date.accessioned2009-06-01T19:32:53Z
dc.date.available1999-06-16en_US
dc.date.available2009-06-01T19:32:53Z
dc.date.issued1999-06-16en_US
dc.description.abstractFreund's complete adjuvant (FCA) treated group of mice when challenged with lethal Plasmodium berghei showed increased survival value; survival period (SP) and median survival day (MSD) compared to their respective control groups. K values were affected and mean parasitaemia during infection period was lower than that of control. In general survival rate after 35 days of infection was 10.5% in FCA recipients. The survival rate in a particular group of animals which received 0.2 ml FCA 3 days before challenge was 22.7%. FCA was found to contribute to increased survival of the host against P. berghei infection. The study indicates that adjuvants, like FCA induce protective immunity and future studies should include non-specific immunization against human malaria.en_US
dc.description.affiliationDivision of Biochemistry and Biotechnology, National Institute of Communicable Diseases, Delhi, India.en_US
dc.identifier.citationPillai CR, Usha Devi C. Role of macrophages in experimental malaria: VI--Effect of Freund's complete adjuvant in Plasmodium berghei infected mice. Journal of Communicable Diseases. 1999 Jun; 31(2): 121-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/113032
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshHumansen_US
dc.subject.meshMacrophages --immunologyen_US
dc.subject.meshMalaria --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPlasmodium berghei --immunologyen_US
dc.titleRole of macrophages in experimental malaria: VI--Effect of Freund's complete adjuvant in Plasmodium berghei infected mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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