Cytogenetics investigation in childhood chronic myeloid leukemia.

Simple item page
dc.contributor.authorChinnappan, Den_US
dc.contributor.authorVerma, I Cen_US
dc.contributor.authorChoudhry, V Pen_US
dc.contributor.authorArya, L Sen_US
dc.date.accessioned2000-02-01en_US
dc.date.accessioned2009-05-30T13:00:19Z
dc.date.available2000-02-01en_US
dc.date.available2009-05-30T13:00:19Z
dc.date.issued2000-02-01en_US
dc.description.abstractCytogenetics investigations, mostly from peripheral blood, were carried out in 30 children with CML. Amongst a sample of 30 patients, 18 had chronic myeloid leukemia of adult variety (ACML), while the remaining 12 children had the juvenile type of chronic myeloid leukemia (JCML). Sixteen (88.9%) out of the 18 patients suffering from ACML tested positive for the classical Philadelphia chromosome translocation t(9; 22). Of the remaining two ACML patients, one tested positive for t(9; 13; 22) while no visible chromosomal changes were observed in the other patient. The activity of Nucleolar Organizer Region (NOR) was significantly reduced in 11 (61.1%) of the 18 patients suffering from ACML, when compared to that of 21 normal healthy controls. Ten out of the 12 patients suffering from JCML had normal karyotypes, while monosomy 8 and 21 q deletion were seen in the remaining two patients respectively. Amongst the 30 CML patients, chromosomal abnormalities were observed in 19 patients. Variant Philadelphia chromosome translocation (9; 13; 22) and monosomy B were observed in ACML and JCML, respectively. In two ACML patients, cytogenetic studies were helpful in diagnosis of the disease.en_US
dc.description.affiliationCenter for Human Genetics, University School of Medicine, Boston, MA 02118, USA.en_US
dc.identifier.citationChinnappan D, Verma IC, Choudhry VP, Arya LS. Cytogenetics investigation in childhood chronic myeloid leukemia. Indian Journal of Pediatrics. 2000 Feb; 67(2): 107-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/81255
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCytogenetic Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshNucleolus Organizer Regionen_US
dc.subject.meshPhiladelphia Chromosomeen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleCytogenetics investigation in childhood chronic myeloid leukemia.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Pediatrics