Captopril suppression tests in normotensive individuals.

Simple item page
dc.contributor.authorTavintharan, Sen_US
dc.contributor.authorRajasoorya, Cen_US
dc.contributor.authorSoong, W Cen_US
dc.date.accessioned2009-05-27T20:52:00Z
dc.date.available2009-05-27T20:52:00Z
dc.date.issued2000-03-16en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: We aimed to measure the serial (time related) concentrations of aldosterone and renin after a single dose of 25 mg of captopril in normotensive individuals. With these results, we aim to ascertain the best sampling times for future tests. DESIGN: Six normotensive subjects were studied under two different conditions--once in a supine position and once under normal (erect-position) activity. Each subject was given 25 mg of captopril and his serum aldosterone and renin concentrations measured at half hourly intervals for four hours. Simultaneous half hourly blood pressure measurements were also noted. RESULTS: All subjects showed suppression of aldosterone levels with ingestion of captopril, and in the supine position maximal suppression was consistently observed from the 3rd to the 4th hour after ingestion. When studied in the erect posture, although there was significant suppression, this was not sustained, and a paradoxical rise of aldosterone levels was seen after 2 hours. Renin activity measured during this study showed no consistent patterns. The renin levels were unchanged in almost 40 per cent of cases, and raised in about 60 per cent of cases. None of the subjects had symptomatic postural hypotension after 25 mg of captopril. CONCLUSIONS: The captopril suppression test is safe and effective in assessing the suppressibility of aldosterone and the period of maximal suppression is from the 3rd to the 4th hour after oral ingestion of captopril.en_US
dc.description.affiliationDepartment of Medicine, Alexandra Hospital, Singapore.en_US
dc.identifier.citationTavintharan S, Rajasoorya C, Soong WC. Captopril suppression tests in normotensive individuals. Journal of the Medical Association of Thailand. 2000 Mar; 83(3): 225-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43777
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAldosterone --blooden_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors --diagnostic useen_US
dc.subject.meshBlood Pressure Determination --methodsen_US
dc.subject.meshCaptopril --diagnostic useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRenin --blooden_US
dc.subject.meshRenin-Angiotensin System --drug effectsen_US
dc.subject.meshSensitivity and Specificityen_US
dc.titleCaptopril suppression tests in normotensive individuals.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand