Chronic rhinosinusitis and recurrent nasal polyps in two children with IgG subclass deficiency and review of the literature.

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dc.contributor.authorChinratanapisit, Sasawanen_US
dc.contributor.authorTunsuriyawong, Prayuthen_US
dc.contributor.authorVichyanond, Pakiten_US
dc.contributor.authorVisitsunthorn, Nualanongen_US
dc.contributor.authorLuangwedchakarn, Voravichen_US
dc.contributor.authorJirapongsananuruk, Orathaien_US
dc.date.accessioned2009-05-27T21:49:21Z
dc.date.available2009-05-27T21:49:21Z
dc.date.issued2005-11-22en_US
dc.descriptionChotmaihet Thangphaet. 26 references.en_US
dc.description.abstractChronic rhinosinusitis (CRS) is a chronic inflammatory disorder of mucosa of the nose and the paranasal sinuses. Two major forms of CRS can be differentiated; CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). The pathophysiology and etiology of nasal polyps (NPs) are partly understood. IgG subclass deficiency was shown to be associated with an increased susceptibility to infections. However the association between NPs and IgG subclass deficiency has never been reported. OBJECTIVES: To report two cases of recalcitrant CRS and recurrent NPs with IgG subclass deficiency. CASE REPORT: Two children (6 and 8 year-old boys) were referred to the Pediatric Allergy/Immunology Clinic, Siriraj Hospital due to a prolonged history of CRS and recurrent NPs. Both of them were treated with aggressive medical (topical and systemic corticosteroids, antibiotics, leukotriene antagonist, nasal irrigation) as well as surgical therapy, without significant improvement. Immunologic investigation in both patients showed that IgG, IgA, and IgM level were normal. IgG subclasses level in patient No. 1 were IgG1 1,235 (280-1120) mg/dl (79%), IgG2 235 (30-630) mg/dl (23.5%), IgG3 27.3 (40-250) mg/dl (1.74%), and IgG4 92.4 (11-620) mg/dl (5.9%). IgG subclasses level in patient No. 2 were IgG1 1,139 (280-1120) mg/dl (82.5%), IgG2 170 (30-630) mg/dl (12.3%), IgG3 5.6 (40-250) mg/dl (0.4%), IgG4 65.7 (11-620) mg/dl (4.8%). The diagnosis of CRS and recurrent NPs with IgG3 subclass deficiency in the first patient and IgG2/IgG3 subclass deficiency in the second patient were made. Patient No. 1 was given monthly IVIG therapy for the total of 7 courses and medications were gradually tapered. Currently, the patient is doing well after the cessation of IVIG therapy for 3 months. Patient No. 2 denied the IVIG treatment and was lost to follow up. CONCLUSION: We reported two cases of recalcitrant CRS and recurrent NPs in children. Immunologic work up revealed IgG subclass deficiency. The treatment with monthly IVIG improved CRS and NPs in treated patient which brought up the possibility of association between NPs and IgG subclass deficiency. Further study on the direct role of IVIG in NPs will be needed in the future.en_US
dc.description.affiliationDivision of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.en_US
dc.identifier.citationChinratanapisit S, Tunsuriyawong P, Vichyanond P, Visitsunthorn N, Luangwedchakarn V, Jirapongsananuruk O. Chronic rhinosinusitis and recurrent nasal polyps in two children with IgG subclass deficiency and review of the literature. Journal of the Medical Association of Thailand. 2005 Nov; 88 Suppl 8(): S251-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45463
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshChilden_US
dc.subject.meshEndoscopyen_US
dc.subject.meshHumansen_US
dc.subject.meshIgG Deficiency --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNasal Mucosa --pathologyen_US
dc.subject.meshNasal Polyps --diagnosisen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRhinitis --immunologyen_US
dc.subject.meshSinusitis --immunologyen_US
dc.titleChronic rhinosinusitis and recurrent nasal polyps in two children with IgG subclass deficiency and review of the literature.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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