The prevalence of pruritus gravidarum and its relation with intrahepatic cholestasis of pregnancy

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dc.contributor.authorChoudhary, L.en_US
dc.contributor.authorKaur, A. P.en_US
dc.contributor.authorKaur, T.en_US
dc.contributor.authorKaur, K.en_US
dc.date.accessioned2024-09-24T09:17:17Z
dc.date.available2024-09-24T09:17:17Z
dc.date.issued2023-05
dc.description.abstractBackground: Pruritus is a common complaint amongst pregnant woman, affecting 20% of them. This can be physiological or due to some specific dermatological conditions. Among them Intrahepatic cholestasis of pregnancy is most common cause and is characterized by pruritus with derranged liver enzymes and raised serum bile acid levels in the absence of any other liver pathology. It is associated with increased fetomaternal morbidity. Methods: This was a prospective study, conducted at Bebe Nanki Mother and Child Care Centre, Government Medical College, Amritsar in the Department of Obstetrics and Gynaecology with collaboration of Dermatology Department, from March 2021 to Aug 2022. After taking ethical approval, informed consent, detailed history, clinical and biochemical assessment was done and fetomaternal outcome was recorded. Results: Prevalance of pruritus was 20.8% amongst pregnant women, of which 24% patients were diagnosed having intrahepatic cholestasis of pregnancy (ICP) and 76% were labelled as NON ICP patients. Among NON ICP patients prevalence of pruritic urticarial papules and plaques of pregnancy was 32.10%. Majority intrahepatic cholestasis of pregnancy patients had moderately affected quality of life. Majority of pruritic patients had normal bilirubin levels and all intrahepatic cholestasis of pregnancy patients had raised serum Alanine transaminase, Aspartate transaminase, bile acids values. Meconium stained liquor, preterm delivery, Low birth weight, cesarean rates, NICU admissions rates were higher in intrahepatic cholestasis of pregnancy patients. Conclusions: Pruritus in pregnancy is a common condition. Dermatological opinion along with liver function tests should be done to know about the cause and severity of pruritus. Intrahepatic cholestasis of pregnancy (ICP) affects perinatal outcomes. So patients should be closely monitored to improve the fetomaternal outcome.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, Government Medical College, Amritsar, Punjab, Indiaen_US
dc.identifier.citationChoudhary L., Kaur A. P., Kaur T., Kaur K.. The prevalence of pruritus gravidarum and its relation with intrahepatic cholestasis of pregnancy. International Journal of Research in Medical Sciences. 2023 May; 11(5): 1698-1703en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/233416
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20231339en_US
dc.subjectFetomaternal outcomesen_US
dc.subjectIntrahepatic cholestasis of pregnancyen_US
dc.subjectMeconium stained liquoren_US
dc.subjectPruritus in pregnancyen_US
dc.titleThe prevalence of pruritus gravidarum and its relation with intrahepatic cholestasis of pregnancyen_US
dc.typeJournal Articleen_US
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