A Study on the Impact of Diabetes Mellitus on the Severity of COVID-19-Associated Mucormycosis

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dc.contributor.authorMadan, Siddharthen_US
dc.contributor.authorDutta, Shellyen_US
dc.contributor.authorYadav, Rekhaen_US
dc.contributor.authorRohatgi, Jollyen_US
dc.contributor.authorBajaj, Ishitaen_US
dc.contributor.authorTadu, Nampien_US
dc.contributor.authorSharma, Rahulen_US
dc.contributor.authorDas, Gopal Krushnaen_US
dc.contributor.authorSahu, Pramod Kumaren_US
dc.contributor.authorGupta, Neelimaen_US
dc.date.accessioned2023-07-21T11:28:16Z
dc.date.available2023-07-21T11:28:16Z
dc.date.issued2023-01
dc.description.abstractObjectives: Diabetes mellitus (DM) seems the most common predisposing factor for rhino-orbito-cerebral mucormycosis (ROCM). This study aimed to study the impact of DM on the severity of COVID-19-associated ROCM (CAM). Methods:?This was a retrospective analytical study performed over a period of 3 months to assess the impact of DM on the severity of CAM in 100 patients and association of clinical correlates of DM with severity of CAM. Statistical analysis:?The data collected using the study tools were converted into a computer-based spreadsheet and analyzed. The statistical analysis comprised a descriptive analysis that involved calculating means, standard deviations, and proportions. For calculating the significance of the difference of mean between two groups, Student's t-test was applied. In addition, chi-square test (or Fisher's t-test if applicable) was applied to study the significance of association of clinical correlates of DM with severity of CAM for categorical variables and t-test for continuous variables. Results:?The prevalence of DM was 67%. The average presenting blood sugar level was 245.9?±?99.86?mg%. Glycated hemoglobin level between 4.5 and 6.5% was observed in 57 patients and over 6.5% in 43 subjects. A high body mass index (BMI) of 25 and above was noted in 52 patients. A significantly higher level of presenting blood sugar and a longer duration of hospital stay was noted in patients having stage 3b or higher (p?<?0.05) when compared with those having stage 3a or below. No significant correlation was observed in patients in stage 3a or below and those presenting with stage 3b or higher in terms of BMI, waist to hip ratio, or total cholesterol levels. There was a strong correlation between blood sugar level at presentation, severity of DM with the severity of ROCM, and a strong inverse correlation noted between HDL level and severity of ROCM. Conclusion:?A poor metabolic control is associated with a higher risk of a severe disease with intracranial involvement.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, University College of Medical Sciences and Associated GTB Hospital, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of ENT, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.citationMadan, Siddharthen_US
dc.identifier.citationDutta, Shellyen_US
dc.identifier.citationYadav, Rekhaen_US
dc.identifier.citationRohatgi, Jollyen_US
dc.identifier.citationBajaj, Ishitaen_US
dc.identifier.citationTadu, Nampien_US
dc.identifier.citationSharma, Rahulen_US
dc.identifier.citationDas, Gopal Krushnaen_US
dc.identifier.citationSahu, Pramod Kumaren_US
dc.identifier.citationGupta, Neelima. A Study on the Impact of Diabetes Mellitus on the Severity of COVID-19-Associated Mucormycosis. Annals of the National Academy of Medical Sciences. 2023 Jan; 59(1): 27-35en_US
dc.identifier.issn0379-038X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220217
dc.languageenen_US
dc.publisherThieme Medical and Scientific Publishers Pvt. Ltden_US
dc.relation.issuenumber1en_US
dc.relation.volume59en_US
dc.source.urihttps://doi.org/10.1055/s-0042-1759890en_US
dc.subjectROCMen_US
dc.subjectCOVID-19en_US
dc.subjectorbital mucormycosisen_US
dc.subjectdiabetes mellitusen_US
dc.subjectcorticosteroidsen_US
dc.titleA Study on the Impact of Diabetes Mellitus on the Severity of COVID-19-Associated Mucormycosisen_US
dc.typeJournal Articleen_US
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