Pattern of celiac disease in infants and children.

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dc.contributor.authorAssiri, Asaad M Aen_US
dc.contributor.authorEl Mouzan, Mohammed Ien_US
dc.contributor.authorAl Sanie, Abdullahen_US
dc.contributor.authorAl Jurayyan, Nasiren_US
dc.contributor.authorAl Herbish, Abdullah Sen_US
dc.contributor.authorBakr, Abdullah Aboen_US
dc.date.accessioned2008-10-28en_US
dc.date.accessioned2009-06-04T03:34:31Z
dc.date.available2008-10-28en_US
dc.date.available2009-06-04T03:34:31Z
dc.date.issued2008-10-28en_US
dc.description.abstractThis study involved all children with celiac disease admitted and seen in the Paediatric Gastroenterology Clinic at King Khalid University Hospital (KKUH) over a 10-year period. In the first year, we identified 62 cases with celiac disease. Their mean age at presentation, introduction to cereals in the diet, and onset of symptoms were 6.5, 6 and 6 months, respectively, and most of the children belonged to the indigenous population. There were three Arabia families with more than one affected child and most families were of good social status. The main symptoms noted were diarrhoea in 34 (57%), growth failure in 47 (74.6%), abdominal distension in 21 (33%), and vomiting in 14 patients (14%). The significant physical signs at the time of presentation were short stature, seen in 44 patients (69.8%), pallor in 25 (40.3%) and abdominal distention in 21 (33%). The mean haemoglobin, serum feritin, serum folate, calcium, and serum albumin were 10.25 g/dL, 2.49 g/mL, 0.25 ng/mL, 8.86 mg/dL, and 3.7 g/dL. The mean anti-reticulin IgG, anti-endomyseal IgG, IgA and anti-gliadin IgG, IgA were one in 246, 332, 720, 121 and 300 units. There was total villous atrophy in each patient at the time of initial presentation; repeat small bowel biopsies were done in 12 patients of whom 6, 4 and 2 had normal villi, partial villous atrophy and subtotal villous atrophy, respectively. A third biopsy was performed in 2 patients while on gluten containing diet, which revealed villous atrophy. Most of the children improved on gluten-free diet.en_US
dc.description.affiliationDivision of Paediatric Gastroenterology & Endocrinology, Department of Paediatrics, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. prof.asaad@hotmail.comen_US
dc.identifier.citationAssiri AM, El Mouzan MI, Al Sanie A, Al Jurayyan N, Al Herbish AS, Bakr AA. Pattern of celiac disease in infants and children. Tropical Gastroenterology. 2008 Oct-Dec; 29(4): 217-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124365
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshCeliac Disease --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSaudi Arabiaen_US
dc.titlePattern of celiac disease in infants and children.en_US
dc.typeJournal Articleen_US
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