Effects of antimalarial drugs on human natural killer cell activity.

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dc.contributor.authorChaicumpa, Wen_US
dc.contributor.authorRoca, R Ven_US
dc.contributor.authorAtthasishtha, Nen_US
dc.contributor.authorChongsuphajaisiddhi, Ten_US
dc.date.accessioned2009-05-27T16:01:20Z
dc.date.available2009-05-27T16:01:20Z
dc.date.issued1983-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSeparation of null cell fraction from the other cellular components of human peripheral blood obtained from normal healthy individuals was effected through the Ficoll-Hypaque density gradient centrifugation, carbonyl iron phagocytosis-magnet application, E-rosette forming and binding to 19S-EAC respectively. The null cells were used as effector cells in the cytotoxic assay. The spontaneous cell-mediated cytotoxicity assay was employed and the highly NK-sensitive K562 labelled with Na251 CrO4 were used as targets. The null cell fraction was divided into several portions to allow for normal control, diluent control and tests. The test portions were those exposed to the various antimalarial drugs employed. It was observed that the T cell, B cells and null cell fractions accounted for 72%, 18% and 10% of the total lymphocyte population respectively. The mean cytotoxicity generated by the natural killer subset was 63%. The antimalarial drugs/drug combination used were chloroquine, quinine, pyrimethamine and sulfadoxine/pyrimethamine combination. Concentrations used were their respective minimal inhibitory concentration (MIC) and corresponding 5 X MIC. The inhibitory effects on natural killer cell activity of these drugs were observed. The possible reasons for these observations are discussed.en_US
dc.identifier.citationChaicumpa W, Roca RV, Atthasishtha N, Chongsuphajaisiddhi T. Effects of antimalarial drugs on human natural killer cell activity. The Southeast Asian Journal of Tropical Medicine and Public Health. 1983 Sep; 14(3): 413-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34228
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAntimalarials --pharmacologyen_US
dc.subject.meshB-Lymphocytes --drug effectsen_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKiller Cells, Natural --drug effectsen_US
dc.subject.meshLymphocytes --drug effectsen_US
dc.subject.meshLymphocytes, Null --drug effectsen_US
dc.subject.meshMalaria --metabolismen_US
dc.subject.meshPotassium --metabolismen_US
dc.subject.meshPyrimethamine --pharmacologyen_US
dc.subject.meshQuinine --pharmacologyen_US
dc.subject.meshSodium --metabolismen_US
dc.subject.meshT-Lymphocytes --drug effectsen_US
dc.titleEffects of antimalarial drugs on human natural killer cell activity.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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