Comparison of bioavailability and pharmacodynamics of diltiazem from two pharmaceutical preparations.

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dc.contributor.authorDange, S Ven_US
dc.contributor.authorNandal, D Hen_US
dc.contributor.authorGokhale, V Sen_US
dc.contributor.authorShah, K Uen_US
dc.contributor.authorKadam, D Ben_US
dc.date.accessioned1992-07-01en_US
dc.date.accessioned2009-06-01T07:42:12Z
dc.date.available1992-07-01en_US
dc.date.available2009-06-01T07:42:12Z
dc.date.issued1992-07-01en_US
dc.description.abstractDiltiazem, a calcium channel blocker, is used in multiple divided doses daily, due to its short elimination half-life. Hence, administration as a modified release (MR) formulation is suggested. In this double blind cross-over trial, the pharmacokinetics and pharmacodynamics of diltiazem was studied in eight healthy Indian adults. Diltiazem was administered as single dose (60 mg) of the two formulations viz immediate release (IR) and MR. Venous blood samples, for estimation of diltiazem by HPLC, were collected at frequent intervals and BP, HR and ECG were monitored during the 12h study period. With MR formulation, plasma half-life was significantly (P < 0.05) prolonged (6.25 +/- 1.2 h vs. 2.69 +/- 0.2 h), the extent of alterations in BP, HR and PR interval was significantly less, while the duration of prolongation of PR interval was significantly more as compared to IR formulation. Therefore, MR formulation of diltiazem has better pharmacokinetic and pharmacodynamic profile as compared to IR formulation.en_US
dc.description.affiliationDepartment of Pharmacology, B. J. Medical College, Pune, Maharastara State.en_US
dc.identifier.citationDange SV, Nandal DH, Gokhale VS, Shah KU, Kadam DB. Comparison of bioavailability and pharmacodynamics of diltiazem from two pharmaceutical preparations. Indian Journal of Physiology and Pharmacology. 1992 Jul; 36(3): 205-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108357
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Availabilityen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshDiltiazem --administration & dosageen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.titleComparison of bioavailability and pharmacodynamics of diltiazem from two pharmaceutical preparations.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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