The Thai anesthesia incident monitoring study of perioperative allergic reactions: an analysis of 1996 incidents reports.

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dc.contributor.authorLapisatepun, Worawuten_US
dc.contributor.authorCharuluxananan, Somraten_US
dc.contributor.authorKusumaphanyo, Chaiyapruken_US
dc.contributor.authorIttichaikulthol, Wichaien_US
dc.contributor.authorSuksompong, Sirilaken_US
dc.contributor.authorRatanachai, Prapaen_US
dc.date.accessioned2009-05-27T18:23:37Z
dc.date.available2009-05-27T18:23:37Z
dc.date.issued2008-10-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVES: Analyze the clinical course, management, outcome, and contributing factors of perioperative allergic reactions in the Thai Anesthesia Incident Monitoring Study (Thai AIMS). MATERIAL AND METHOD: A prospective descriptive multicenter study was conducted in 51 hospitals across Thailand Voluntary, anonymous reports of any adverse or undesirable events during the first 24 hours of anesthesia were sent to the Thai AIMS data management unit. Possible perioperative allergic reactions were extracted and examined independently by three peer reviewers. RESULTS: Forty-three reports of possible perioperative allergic reactions from the 2,537 incidents reported to the Thai AIMS (1.6%) were reviewed. There was a female predominance (1.9:1). The most common features were cutaneous manifestations (93%), arterial hypotension (20.1%), and bronchospasm (11.6%) respectively. The severity grades were 69.8% in grade I, 4.7% in grade II, and 25.6% in grade III. The three most suspected causative agents were neuromuscular blocking agents (39.5%, 30.2%-succinylcholine), antibiotics (27.9%), and opioids (18.6%) respectively. All but one responded well to treatment with complete recovery. One patient suffered acute myocardial infarction and had to stay at the hospital for longer than one week. None had further allergic reaction. CONCLUSION: Perioperative allergic reactions accounted for 1.6% of anesthetic adverse events. The most common features were cutaneous manifestations. A quarter of these were life-threatening but responded well to treatment. The most common suspected causative agent was succinylcholine.en_US
dc.description.affiliationDepartment of Anesthesiology, Chiang Mai University, Chiang Mai, Thailand.en_US
dc.identifier.citationLapisatepun W, Charuluxananan S, Kusumaphanyo C, Ittichaikulthol W, Suksompong S, Ratanachai P. The Thai anesthesia incident monitoring study of perioperative allergic reactions: an analysis of 1996 incidents reports. Journal of the Medical Association of Thailand. 2008 Oct; 91(10): 1524-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39055
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAdverse Drug Reaction Reporting Systemsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAnalgesics, Opioid --adverse effectsen_US
dc.subject.meshAnesthesia --adverse effectsen_US
dc.subject.meshAnti-Bacterial Agents --adverse effectsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDrug Hypersensitivityen_US
dc.subject.meshDrug Monitoringen_US
dc.subject.meshFemaleen_US
dc.subject.meshHealth Status Indicatorsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypersensitivityen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeuromuscular Agents --adverse effectsen_US
dc.subject.meshPerioperative Careen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSuccinylcholine --adverse effectsen_US
dc.subject.meshThailanden_US
dc.subject.meshYoung Adulten_US
dc.titleThe Thai anesthesia incident monitoring study of perioperative allergic reactions: an analysis of 1996 incidents reports.en_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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