Comparison of clinicopathological characteristics of endogenous and exogenous cervical cancer with its clinical significance

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dc.contributor.authorChoudhry, Farihaen_US
dc.contributor.authorMuhammad, Tahiren_US
dc.contributor.authorYou, Xuewuen_US
dc.contributor.authorLiu, Luen_US
dc.contributor.authorAbdulaziz, Asrar M. A.en_US
dc.contributor.authorSun, Yuen_US
dc.contributor.authorCui, Baoxiaen_US
dc.contributor.authorHan, Saien_US
dc.contributor.authorZhang, Youzhongen_US
dc.date.accessioned2020-11-18T10:10:37Z
dc.date.available2020-11-18T10:10:37Z
dc.date.issued2020-03
dc.description.abstractBackground:Cervical cancer is the third leading cause of cancer death in women of less developed countries due to poor screening and decreased diagnostic approaches. We aimed to investigate and differentiate the distinct clinicopathological characteristics and prevalence of endogenous and exogenous cervical in hospitalized patients. Methods:A study was performed contained 663 patients that were enrolled and underwent for screening of endogenous and exogenous cervical cancer in Qilu Hospital of Shandong University, from January 2010 to March 2015.Results:Our results indicated that combined examination of thin-prep liquid-based cytology test and human papillomavirus(HPV)-DNA are effective for diagnosis of endogenous and exogenous cervical cancer. The clinicopathological characteristics based on tumor growth pattern, and highrisk HPV-DNA incidence had no significant difference (p>0.05) in endogenous and exogenous cervicalcancer patients. The higher ratio of lymph node metastasis in endogenous cervical cancer and exogenous cervical cancer during IB1-stage (24.3% vs 12.9%), and in IIA2-stage (36.4% vs 25%) was observed respectively. In addition, our data provide compelling evidence that the level of deep interstitial infiltration, and lymphatic vascular infiltration in endogenous cervical cancer was collectively higher (82.7% and 33%) compared to exogenous cervical cancer (62.4% and18.3%) respectively during all stages.Conclusions:The higher percentage of lymph node metastasis,deep interstitial infiltration, and lymphatic vascular infiltration was observed in endogenous cervical cancer which might be the biomarker and differential key points for the diagnosis of endogenous cervical cancer. Taken together, our study provides clinicopathological features to diagnose, and differentiate the endogenous and exogenous type cervical cancer with its prevalence.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsCenter for Reproductive Medicine, Shandong University,Shandong, Chinaen_US
dc.identifier.affiliationsNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, Chinaen_US
dc.identifier.citationChoudhry Fariha, Muhammad Tahir, You Xuewu, Liu Lu, Abdulaziz Asrar M. A., Sun Yu, Cui Baoxia, Han Sai, Zhang Youzhong. Comparison of clinicopathological characteristics of endogenous and exogenous cervical cancer with its clinical significance. International Journal of Scientific Reports. 2020 Mar; 6(3): 83-89en_US
dc.identifier.issn2454-2456
dc.identifier.issn2454-2164
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214006
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org//10.18203/issn.2454-2156.IntJSciRep20200566en_US
dc.subjectCervical canceren_US
dc.subjectEndogenous cervical canceren_US
dc.subjectExogenous cervical canceren_US
dc.subjectLymph node metastasisen_US
dc.titleComparison of clinicopathological characteristics of endogenous and exogenous cervical cancer with its clinical significanceen_US
dc.typeJournal Articleen_US
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