Blocking of enhanced sensitivity to behavioral effects of naloxone induced by narcotic agonists in rats.

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dc.contributor.authorJain, Rakaen_US
dc.contributor.authorRay, Rajaten_US
dc.date.accessioned2003-10-23en_US
dc.date.accessioned2009-06-01T06:16:54Z
dc.date.available2003-10-23en_US
dc.date.available2009-06-01T06:16:54Z
dc.date.issued2003-10-23en_US
dc.description.abstractThe present experiment evaluated whether prior treatment with naloxone could block the sensitization to opiate antagonist induced by single dose administration of pure agonist (morphine) or mixed agonist (buprenorphine). Food deprived male Wistar rats were trained to respond for food on a multiple-trial, fixed-interval 3 min schedule. Reinforcement was contingent upon a response within a 10-s limited hold period following a fixed-interval of 3 min. A trial consisted of three fixed interval of 3 min separated by a 10 min timeout period during which responses were not reinforced. The rate decreasing effects of the opioid antagonist naloxone was determined by cumulative dosing. Pretreatment with morphine (0.3 mg/ kg, SC) and buprenorphine (0.03 mg/kg, SC) resulted in an increase sensitivity to the rate decreasing effect of naloxone compared to saline pretreatment. Administration of naloxone (0.3 mg/kg) 10 min prior to pretreatment doses of buprenorphine (0.03 mg/kg; 1.0 mg/kg) and morphine (0.3 mg/kg) increased sensitization to naloxone. However, greater sensitization was observed at low dose of buprenorphine. The increased sensitivity was partially blocked at high dose of buprenorphine (1.0 mg/ kg) by naloxone pretreatment. These results suggest that the doses of naloxone used to block opioid induced sensitization might be different from those required in animals with normal sensitivity to opioid antagonists. Further agonist-induced sensitization to behavioral effects of opioid antagonist appears to be opioid receptor specific.en_US
dc.description.affiliationDepartment of Psychiatry, National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi 110 029. rakajain2001@yahoo.comen_US
dc.identifier.citationJain R, Ray R. Blocking of enhanced sensitivity to behavioral effects of naloxone induced by narcotic agonists in rats. Indian Journal of Physiology and Pharmacology. 2003 Oct; 47(4): 407-14en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107265
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnalgesics, Opioid --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFood Deprivation --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNaloxone --pharmacologyen_US
dc.subject.meshNarcotic Antagonists --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshReaction Time --drug effectsen_US
dc.titleBlocking of enhanced sensitivity to behavioral effects of naloxone induced by narcotic agonists in rats.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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