Isosexual precocity: the clinical and etiologic profile.

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dc.contributor.authorDesai, Men_US
dc.contributor.authorColaco, M Pen_US
dc.contributor.authorChoksi, C Sen_US
dc.contributor.authorAmbadkar, M Cen_US
dc.contributor.authorVaz, F Een_US
dc.contributor.authorGupte, Cen_US
dc.date.accessioned1993-05-01en_US
dc.date.accessioned2009-05-27T04:55:21Z
dc.date.available1993-05-01en_US
dc.date.available2009-05-27T04:55:21Z
dc.date.issued1993-05-01en_US
dc.description.abstractEighty children (58 girls and 22 boys) with isosexual precocity seen in the past eight years were evaluated clinically and investigated to identify the underlying cause. Of these, 50% (29 girls and 11 boys) had centrally mediated true precocious puberty (TPP). The girls could be classified into five major groups (I) Central precocious puberty 29-subclassified into idiopathic (ITPP, 15) and organic or neurogenic (NTTP, 14), (II) Premature thelarche (PT, 20), (III) Premature menarche (PM, 2), (IV) Premature adrenarche (PA, 5), and, (V) Others: hypothyroid (n = 1), and McCune Albright Syndrome (n = 1). ITPP as a cause of precocity in girls was seen less often (52%) and NTPP more often (48%) compared to most Western series, with tubercular meningitis as the cause in 31% and hypothalamic hamartomas in 10%. Though the LH and estradiol levels were significantly higher (p < 0.05) in TPP, compared to PT, these were not helpful in differentiating because of considerable overlap. LH-predominant-response (LH/FSH ratio > 1) to LHRH testing was seen in TPP. Amongst the 22 boys, 11 (50%) had TPP, ITPP in 27% and NTPP in 73%. Hamartomas (n = 4) and TBM (n = 3) contributed equally to NTPP; pineal tumor was seen in one. The adrenal (n = 7) and testicular (n = 2) causes together involved 41% of the boys with precocity, congenital adrenal hyperplasia (CAH) CAH, 11-beta hydroxylase being the commonest cause. Of the 6 boys witdeficiency was found in four and nonsalt losing form of 21-hydroxylase deficiency in 2. Testicular and adrenal tumors and testotoxicosis were noted in one case each. The etiologic factors were more varied in boys.en_US
dc.description.affiliationDivision of Pediatric Endocrinology, Bai Jerbai Wadia Hospital for Children, Bombay.en_US
dc.identifier.citationDesai M, Colaco MP, Choksi CS, Ambadkar MC, Vaz FE, Gupte C. Isosexual precocity: the clinical and etiologic profile. Indian Pediatrics. 1993 May; 30(5): 607-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/6415
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAdrenal Gland Diseases --complicationsen_US
dc.subject.meshAge Determination by Skeletonen_US
dc.subject.meshBreast --growth & developmenten_US
dc.subject.meshCentral Nervous System Diseases --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMenarche --physiologyen_US
dc.subject.meshPenis --growth & developmenten_US
dc.subject.meshPuberty, Precocious --classificationen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTesticular Diseases --complicationsen_US
dc.titleIsosexual precocity: the clinical and etiologic profile.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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