Study on serum transcobalamin II in patients with murine typhus.

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dc.contributor.authorCheeramakara, Cheeraratanaen_US
dc.contributor.authorSongmeang, Kriyapornen_US
dc.contributor.authorNakosiri, Wanyaraten_US
dc.contributor.authorSuthisai, Nopachaien_US
dc.contributor.authorNontprasert, Apicharten_US
dc.contributor.authorAreekul, Suviten_US
dc.date.accessioned2009-05-27T15:37:09Z
dc.date.available2009-05-27T15:37:09Z
dc.date.issued2006-05-06en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractWe measured the serum transcobalamin II in murine typhus- infected patients (n = 16) admitted to the Hospital for Tropical Diseases in 1996-1997, compared with healthy controls (n = 60). The results showed that the transcobalamin II (TCII) and total serum unsaturated vitaminB12 binding capacity (UBBC) in patients with murine typhus (2,126.5 pg/ml, range 1,262-4,568 and 3,771.5 pg/ml, range 1,576-6,763 pg/ml) were statistically significantly higher than normal subjects (987.5 pg/ml, range 678-2,000 pg/ml and 1,402 pg/ml, range 932-2,470 ml) (p<0.001). Serum TCII levels in patients (63%) were elevated during the febrile period and returned to normal post-treatment. These findings suggest that patients with murine typhus had stimulation of reticulo-endothelial system, spleen, mesenteric lymph nodes, liver and skin and then released TCII into the blood circulation. The elevation in TCII may be used for confirming a diagnosis of murine typhus.en_US
dc.description.affiliationDepartment of Tropical Radioisotopes, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. tmccr@mahidol.ac.then_US
dc.identifier.citationCheeramakara C, Songmeang K, Nakosiri W, Suthisai N, Nontprasert A, Areekul S. Study on serum transcobalamin II in patients with murine typhus. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 ; 37 Suppl 3(): 145-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33236
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2006_37_spp3/37sup3_145.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTranscobalamins --analysisen_US
dc.subject.meshTyphus, Endemic Flea-Borne --blooden_US
dc.titleStudy on serum transcobalamin II in patients with murine typhus.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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