Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi
dc.contributor.author | K, MN | en_US |
dc.contributor.author | S, K | en_US |
dc.contributor.author | K, MJ | en_US |
dc.contributor.author | N, SG | en_US |
dc.contributor.author | B, R | en_US |
dc.contributor.author | M, S | en_US |
dc.contributor.author | A, S | en_US |
dc.contributor.author | Latheef, NA | en_US |
dc.contributor.author | A, M | en_US |
dc.contributor.author | K, RB | en_US |
dc.date.accessioned | 2020-09-24T07:56:04Z | |
dc.date.available | 2020-09-24T07:56:04Z | |
dc.date.issued | 2019-05 | |
dc.description.abstract | Background: Tuberculosis (TB) is one of the top ten causes of mortality and the leading cause of a single infectious agent. Unfortunately, India is home to approximately one-fourth of drug-resistant (DR)-TB cases globally. Despite all the developments in TB, the disease is becoming an important threat to public health. Objective: The present analysis was done to describe the profile and assess and compare the outcome of DR-TB patient admitted in DR-TB ward, Sir Sunderlal Hospital (SSH), Banaras Hindu University (BHU). Materials and Methods: Retrospective analysis of data from 2013 to 2018 of multi-DR (MDR)-TB patients admitted in DR-TB ward, SSH, Institute of Medical Sciences, BHU and treatment initiated after pre-treatment evaluation was conducted. Patients were referred from nearby nine districts of Uttar Pradesh. After pre-treatment evaluation treatment was initiated at DR-TB center, SSH as well as in their respective district. Results: A total of 3234 (76.7%) MDR-TB patients out of 4216 MDR-diagnosed patients were initiated on standard treatment which has increased from 74% in 2013. More than 93% of the cases were older than 15 years of age with slightly male predominance. The majority (>96%) of the cases were pulmonary TB. In the present analysis conversion of MDR-TB to extensively DR-TB (XDR-TB) was 7.7%. The treatment success rate for XDR-TB had also significantly improved from 11% in 2015 to 34% in 2017. Conclusion: Analysis shows 7.7% MDR patients converted into XDR; hence, there is a strong need to explore factors responsible for conversion. 7% of patients were <15 years of age indicating the need for separate pediatric DR-TB ward. 18% of DR-TB patients were defaulters; hence, the reason for it should be sought and addressed. Treatment success rate for MDR-TB has been seen improved from 40% in 2013 to 48% in 2017. | en_US |
dc.identifier.affiliations | Department of TB and Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | Department of Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | DR-TB Center, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India | en_US |
dc.identifier.citation | K MN, S K, K MJ, N SG, B R, M S, A S, Latheef NA, A M, K RB. Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. International Journal of Medical Science and Public Health. 2019 May; 8(5): 395-400 | en_US |
dc.identifier.issn | 2277-338X | |
dc.identifier.issn | 2320-4664 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/205449 | |
dc.language | en | en_US |
dc.publisher | International Journal of Medical Science and Public Health | en_US |
dc.relation.issuenumber | 5 | en_US |
dc.relation.volume | 8 | en_US |
dc.source.uri | https://dx.doi.org/10.5455/ijmsph.2019.0305326032019 | en_US |
dc.subject | Clinical | en_US |
dc.subject | Epidemiological | en_US |
dc.subject | Multidrug-Resistant | en_US |
dc.subject | Patients | en_US |
dc.subject | Treatment Outcome | en_US |
dc.title | Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi | en_US |
dc.type | Journal Article | en_US |
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