Gastro-duodenal mucosal changes associated with low-dose aspirin therapy: a prospective, endoscopic study.

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dc.contributor.authorChowdhury, Aen_US
dc.contributor.authorGanguly, Gen_US
dc.contributor.authorChowdhury, Den_US
dc.contributor.authorSantra, Aen_US
dc.contributor.authorGupta, J Den_US
dc.contributor.authorRoy, Ten_US
dc.date.accessioned2001-11-31en_US
dc.date.accessioned2009-05-29T02:03:39Z
dc.date.available2001-11-31en_US
dc.date.available2009-05-29T02:03:39Z
dc.date.issued2001-11-31en_US
dc.description.abstractOBJECTIVES: The association of low-dose aspirin use and gastro-intestinal bleeding is well described. However, the gastroduodenal mucosal changes associated with low-dose aspirin therapy have not been properly evaluated. We undertook a prospective, endoscopic study to evaluate gastro-duodenal mucosal lesions produced by low-dose aspirin. METHODS: Forty-seven patients with non-hemorrhagic cerebral infarct or transient ischemic attacks and normal upper gastrointestinal endoscopy were randomized to receive either enteric-coated (n=25) or plain (n=22) aspirin (150 mg/day). Follow-up endoscopy was done at 2, 4 and 8 weeks; gastro-duodenal mucosal lesions, if present, were scored. Forty-seven patients with hemorrhagic infarct who were not treated with aspirin served as controls. RESULTS: Twenty eight (60%) of 47 patients receiving aspirin had mucosal lesions; stomach alone was the most frequent site (32%), followed by both stomach and duodenum (23%). Frequency of mucosal changes in the stomach at 8 weeks (19%) was significantly lower (p<0.05) than those at 2 weeks (53%) and 4 weeks (55%). Coated (56%) and plain (63.6%) aspirin induced mucosal lesions with similar frequency. CONCLUSION: Administration of low-dose aspirin, either plain or enteric-coated, induces endoscopic gastro-duodenal mucosal lesions in a large majority of patients. The frequency of damage decreased after 8 weeks of therapy.en_US
dc.description.affiliationDepartment of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata. achowdhury@apexmail.comen_US
dc.identifier.citationChowdhury A, Ganguly G, Chowdhury D, Santra A, Gupta JD, Roy T. Gastro-duodenal mucosal changes associated with low-dose aspirin therapy: a prospective, endoscopic study. Indian Journal of Gastroenterology. 2001 Nov-Dec; 20(6): 227-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63687
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --administration & dosageen_US
dc.subject.meshAspirin --administration & dosageen_US
dc.subject.meshCerebral Infarction --drug therapyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshEndoscopy, Gastrointestinal --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGastric Mucosa --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestinal Mucosa --drug effectsen_US
dc.subject.meshIschemic Attack, Transient --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTablets, Enteric-Coateden_US
dc.titleGastro-duodenal mucosal changes associated with low-dose aspirin therapy: a prospective, endoscopic study.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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