Formulation and Characterization of Dental Film Containing Ofloxacin.
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Date
2012-11
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Abstract
The aim of the study was to formulate intrapocket dental films, which could be easily placed into the
periodontal pocket, and be capable of delivering therapeutic concentrations of ofloxacin for prolonged
period of time at a much lower dose, hence obviating untoward side effects. Intrapocket device
containing ofloxacin was prepared using 255.20 mg of ofloxacin, 2.0% plasticizer diethyl phthalate and
1.4g ethyl cellulose. The device was optimized on the basis of evaluation parameters such as weight
variation, content uniformity, surface pH, in vitro and in vivo release studies. Films showed sustained in
vitro release for a period of 11 days. In vivo release studies showed that drug concentrations were
maintained above MIC value for entire period of release studies. The samples from this study were
capable of inhibiting the growth of most test strains. Ofloxacin in carrier polymer ethyl cellulose showed
extended spectrum of antimicrobial activity. Stability studies were conducted on optimized formulation
and degradation rate constant was found to be 1.2056 10-4/day. The drug released locally and had high
benefit to low risk ratio as compared to systemic administration, which is unacceptable due to, low
benefit to high-risk ratio. Hence low dose site-specific films is a better alternative.
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Keywords
Periodontal disease, intrapocket device, ofloxacin, microbiological studies
Citation
Ali Md Sajid, Ali Javed, Ahuja Alka, Alam Md Sarfaraz. Formulation and Characterization of Dental Film Containing Ofloxacin. Journal of Applied Pharmaceutical Science. 2012 Nov; 2(11): 114-119.