Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels

Simple item page
dc.contributor.authorAzeez, Aen_US
dc.contributor.authorNair, HSen_US
dc.contributor.authorVasanthakumari, Nen_US
dc.contributor.authorJacob, JTen_US
dc.contributor.authorFathima, S.en_US
dc.date.accessioned2025-05-14T09:32:51Z
dc.date.available2025-05-14T09:32:51Z
dc.date.issued2024-12
dc.description.abstractBackground: Pregnancy-associated plasma protein-A (PAPP-A) is traditionally one of the combined biochemical screening methods for aneuploidies. Though PAPP-A has been found in many human organs, including the colon, kidneys, breast, and bone marrow, it is found more in pregnant woman’s serum due to the production by syncyt- io-trophoblast of the placenta. Recent studies have explored the use of PAPP-A for the prediction of adverse pregnancy outcomes. This study focuses on the obstetric outcomes in pregnant women with low PAPP-A levels. Methods: This was a prospective cohort study conducted in the Department of Obstetrics & Gynaecology, SAT Hospital, Trivandrum among antenatal women of gestational age 11 to 14 weeks. They were followed up to see the difference in pregnancy outcomes between women with low PAPP-A and normal PAPP-A levels. Results: Women with low PAPP-A are at a significantly higher risk of complications as fetal growth restriction, preec- lampsia, preterm birth, low birth weight, and neonatal complications. Conclusion: The study supports the association between low PAPP-A levels and adverse obstetric outcomes. The findings underscore the importance of identifying and closely monitoring pregnant women with low PAPP-A. Future research should focus on elucidating the underlying mechanisms linking low PAPP-A levels with adverse outcomes and exploring potential interventions to mitigate the risks associated with low PAPP-A levels.en_US
dc.identifier.affiliationsConsultant in O&G, Anchal Hospital for Mother and Child, Anchal, Keralaen_US
dc.identifier.affiliationsAssociate Professor in O&G, Government Medical College, Trivandrum, Keralaen_US
dc.identifier.affiliationsAssistant Professor in O&G, Government Medical College, Trivandrum, Keralaen_US
dc.identifier.affiliationsAssistant Professor in O&G, Government Medical College, Trivandrum, Keralaen_US
dc.identifier.affiliationsMedical Officer in O&G, Anchal Hospital for Mother and Child, Anchal, Keralaen_US
dc.identifier.citationAzeez A, Nair HS, Vasanthakumari N, Jacob JT, Fathima S.. Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Dec; 14(12): 2536-2542en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247826
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber12en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.5455/NJPPP.2024.v14.i12.7en_US
dc.subjectPregnant womenen_US
dc.subjectPregnancy complicationsen_US
dc.subjectPregnancy-associated plasma protein-Aen_US
dc.subjectScreeningen_US
dc.titleObstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levelsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
njppp2024v14n12p2536.pdf
Size:
590.16 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Physiology, Pharmacy and Pharmacology