Low incidence of metabolic syndrome in patients taking atypical antipsychotic in Eastern India

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dc.contributor.authorDash, S Sen_US
dc.contributor.authorRavan, J Ren_US
dc.contributor.authorThakur, Ben_US
dc.contributor.authorPasumarthy, Sen_US
dc.contributor.authorKumar, Sen_US
dc.contributor.authorDas, S Ken_US
dc.contributor.authorChowdary, P C.en_US
dc.date.accessioned2023-07-14T06:59:55Z
dc.date.available2023-07-14T06:59:55Z
dc.date.issued2020-06
dc.description.abstractBackground: Atypical antipsychotics, widely used in many psychiatric diseases, are known to cause metabolic syndrome (MetS). But, there is sparse of prospective study to see the effect of atypical antipsychotics causing MetS in drug na飗e or drug free patients among the Indian population. This study aimed to determine the incidence of MetS and change in individual risk factor for MetS in schizophrenia and mood disorder patients after three months of receiving atypical antipsychotics. Method: Sixty patients of schizophrenia (n=40) and mood disorders (n=20) were screened at the baseline and all of them were prospectively followed up for the occurrence of MetS after three months. Results: By applying the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP/ATP III) modified criteria for Asian, the incidence of MetS was found to be 11.66%. When analysing the individual risk factor for MetS, the mean value from baseline to follow-up was weight (in kg) 58.55�.03 to 59.80�.24 (p<0.001), waist circumference (cm) 80.52�33 to 81.43�42 (p<0.001), systolic blood pressure (mm/Hg) 113.93�28 to 117.53�.89 (p<0.001), diastolic blood pressure (mm/Hg) 74.80�31 to 78.32�79 (p<0.001), fasting blood glucose (mg/dl) 86.23�.02 to 91.35�.04 (p<0.001), triglyceride (mg/dl) 97.32�.41 to 101.25�.38 (p<0.001), high-density lipoproteins (HDL) (mg/dl) 48.07�98 to 48.05�57 (p=0.951). Conclusion: Our study suggests that incidence of MetS in Indian population was 11.66% after three months of using atypical antipsychotic drugs in patients with schizophrenia or mood disorder. The change in mean value in the individual risk factor for MetS was statistically significant. Long-term follow-up studies are required to identify the real burden of MetS after using atypical antipsychotic drugs.en_US
dc.identifier.affiliationsVidyasagar University, Midnapore, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry and Behavioural Sciences, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsKalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry and Behavioural Sciences, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry and Behavioural Sciences, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry and Behavioural Sciences, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry and Behavioural Sciences, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationDash S S, Ravan J R, Thakur B, Pasumarthy S, Kumar S, Das S. K, Chowdary P C.. Low incidence of metabolic syndrome in patients taking atypical antipsychotic in Eastern India. Open Journal of Psychiatry & Allied Sciences. 2020 Jun; 11(1): 4-9en_US
dc.identifier.issn2394-2061
dc.identifier.issn2394-2053
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/218352
dc.languageenen_US
dc.publisherAcademy Publisheren_US
dc.relation.issuenumber1en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.5958/2394-2061.2020.00001.4en_US
dc.subjectProspective Studiesen_US
dc.subjectSchizophreniaen_US
dc.subjectMood Disordersen_US
dc.titleLow incidence of metabolic syndrome in patients taking atypical antipsychotic in Eastern Indiaen_US
dc.typeJournal Articleen_US
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