First Trimester Antenatal Ultrasonographic Screening for Aneuploidy - So Far So Good.
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Date
2012-04
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Abstract
Ultrasound has become an integral component of obstetric care, with the vast majority of patients having at least one ultrasound
examination during pregnancy. Recent advances in obstetric ultrasonography (USG) have increased its importance in managing
pregnancies at risk for aneuploidy and structural abnormality. Antenatal screening of aneuploidy, particularly Down syndrome
includes biochemical markers, USG and invasive tests like chorionic villus sampling (CVS) and amniocentesis. In this article,
we review and compare these screening modalities with emphasis on USG. In light of current literature, we will discuss first
trimester sonographic markers associated with aneuploidy viz. nuchal translucency (NT), fetal nasal bone and ductus venosus
flow and their statistical as well as clinical significance in the detection of aneuploidy. We will review the current data and
status of first trimester screening for aneuploidy.
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Keywords
Aneuploidy, prenatal ultrasound, first trimester, nuchal translucency, fetal nasal bone, ductus venosus flow
Citation
Parikh Hetal, Raniga Sameer, Desai Pankaj, Arora Abhishek. First Trimester Antenatal Ultrasonographic Screening for Aneuploidy - So Far So Good. Indian Journal of Clinical Practice. 2012 Apr; 22(11): 550-556.