Is seroprevalence of anti-IGM CMV among blood donors relevant in India?

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dc.contributor.authorKumar, Harshen_US
dc.contributor.authorGupta, P Ken_US
dc.contributor.authorKumar, Satishen_US
dc.contributor.authorSarkar, R Sen_US
dc.date.accessioned2008-07-30en_US
dc.date.accessioned2009-05-29T13:02:21Z
dc.date.available2008-07-30en_US
dc.date.available2009-05-29T13:02:21Z
dc.date.issued2008-07-30en_US
dc.description.abstractBACKGROUND: Infection with cytomegalovirus (CMV) is more common in developing nations and the people belonging to the lower socioeconomic section of the society. The immunosuppressed population for whom CMV-seronegative blood products are requested is increasing due to advances in medical care. AIM: To study the prevalence of CMV antibodies among the different sexes and age groups in healthy blood donors. MATERIALS AND METHODS: A retrospective study was done on 5600 serum samples stored frozen in a repository for CMV antibodies using the ELISA technique. RESULTS: Five thousand three hundred and fifty (95.5%) were male and 250 (4.5%) were female. Four cases (0.071%) out of 5600 samples were positive for anti-IgM CMV with 95% Confidence Interval (95% C.I) of 0.02 - 0.17. CONCLUSION: In a developing country like India, screening for IgM antibody on a routine basis may not be feasible, given the likely positive yield to be low and the cost being high. It is recommended that in a tertiary care hospital, blood units to be transfused to neonates, organ transplant recipients, those suffering from malignancies and other immunocompromised patients should be screened for anti-IgM CMV or preventive strategies like universal leucodepletion to be implemented to decrease the transmission of CMV in these groups of patients.en_US
dc.description.affiliationDepartment of Transfusion Medicine, Armed Forces Medical College, Pune - 411 040, India.en_US
dc.identifier.citationKumar H, Gupta PK, Kumar S, Sarkar RS. Is seroprevalence of anti-IGM CMV among blood donors relevant in India? Indian Journal of Pathology & Microbiology. 2008 Jul-Sep; 51(3): 351-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75229
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Viral --blooden_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshCytomegalovirus Infections --epidemiologyen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assay --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin M --blooden_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.titleIs seroprevalence of anti-IGM CMV among blood donors relevant in India?en_US
dc.typeJournal Articleen_US
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