Efficacy of serum sialoglycoproteins as a biomarker of the disease activity & treatment monitoring in patients with base tongue malignancy.

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dc.contributor.authorJoshi, B Hen_US
dc.contributor.authorJoshi, M Ben_US
dc.contributor.authorPatel, P Sen_US
dc.contributor.authorChitnis, K Een_US
dc.contributor.authorBalar, D Ben_US
dc.date.accessioned1989-02-01en_US
dc.date.accessioned2009-05-27T06:59:10Z
dc.date.available1989-02-01en_US
dc.date.available2009-05-27T06:59:10Z
dc.date.issued1989-02-01en_US
dc.description.abstractSerum levels of sialoglycoprotein constituents i.e., sialic acid, seromucoid hexoses, and mucoid proteins were determined in 34 patients with base tongue malignancy and 15 controls matched for age and sex. All three constituents were found to be significantly raised; however, only sialic acid levels increased with the severity of the disease. More than 92 per cent of the patients in each clinical stage showed abnormal values of hexoses and mucoid proteins in seromucoids. Electrophoretic separation showed a split in alpha-2-glycoprotein at pretreatment time in 67.6 per cent of the patients. On administration of radiotherapy, all three fractions decreased while alpha-2- split disappeared in 61.8 per cent patients and gamma glycoprotein peak emerged at the end of the protocol with a parallel decrease in these three constituents. It may be concluded from the data that serum sialoglycoproteins can be useful to monitor therapy in base tongue malignancy patients.en_US
dc.identifier.citationJoshi BH, Joshi MB, Patel PS, Chitnis KE, Balar DB. Efficacy of serum sialoglycoproteins as a biomarker of the disease activity & treatment monitoring in patients with base tongue malignancy. Indian Journal of Medical Research. 1989 Feb; 90(): 17-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/18803
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMonitoring, Physiologicen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshSialoglycoproteins --blooden_US
dc.subject.meshTongue Neoplasms --blooden_US
dc.subject.meshTumor Markers, Biological --blooden_US
dc.titleEfficacy of serum sialoglycoproteins as a biomarker of the disease activity & treatment monitoring in patients with base tongue malignancy.en_US
dc.typeJournal Articleen_US
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